Development of a Parametric Aortic Valve CAD Model, Fabrication of Testing Samples, and Strategy for in vitro Measurement

The creation of anatomical computer aided design (CAD) models in the effort to replicate in vivo tissue geometry has been used in order to further study the implications of diseases and flow conditions in the region of the aortic valve. With medical imaging data, (e.g. CT, MRI, ultrasound), it is possible to create a three-dimensional (3-D) anatomical model by using lofted surfaces to represent the anatomy. This method makes the model more compatible with the intended simulation and fabrication techniques. Utilizing additive manufacturing techniques, dissolvable molds were developed so that the resulting anatomical models could be cast from Sylgard 184 silicone. The custom housing for the model was developed to replicate the conditions in which the real-life version of the model would be exposed to, and create a viewing window in which this simulated model can be observed. A camera array system and LED based lighting solution has been used for the measurement of the models performance during in vitro testing. Use of MathWorks Computer System Vision Toolbox was employed to process the image data and calculate the displacement of the silicone models. A discourse on the method of creation of the model and the housing in which the model was tested will be provided. The data obtained from this simulated model will further understanding of the anatomy of biological structures and biomechanics while under the pathophysiological conditions that have resulted from the progression various diseases and surgical interventions.