眩晕病检测的生物力学模型

N. Filipovic, Z. Milosevic, I. Šaveljić, D. Nikolić, N. Zdravković, A. Kos
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摘要

良性阵发性位置性眩晕(BPPV)是影响40岁以上人群生活质量的最常见的前庭疾病。在本研究中,描述了半圆管(SCC)的三维生物力学模型,包括颗粒、管壁、丘变形和内淋巴液体流动的全三维流固相互作用。使用Oculus Rift设备进行头动眼动追踪实验结果,并与生物力学模型进行关联。流体域采用完整的Navier-Stokes方程和连续性方程,网格运动采用任意拉格朗日欧拉(ALE)公式。流固耦合是指流体与锥体变形的耦合。粒子跟踪算法用于粒子运动。利用不同大小和数量的颗粒,充分相互作用,壁和丘变形。速度分布,剪应力和力从内淋巴侧的参数一个SCC和患者特异性三个SCC。所有的模型都与相同的实验方案进行了关联,包括头部运动和眼球震颤的眼动追踪。膜偏转的数值模拟结果与跟踪技术检测的眼球震颤反应有很好的相关性。可用于虚拟游戏,对用户进行前庭功能障碍检测。
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Biomechanical Model for Detection of Vertigo Disease
Benign Paroxysmal Positional Vertigo (BPPV) is most common vestibular disorder influencing the quality of life to considerable percentage of population after the age of forty. In this study the three-dimensional biomechanical model of the semi-circular canal (SCC) is described with full 3D fluid-structure interaction of particles, wall, cupula deformation and endolymph fluid flow. Oculus Rift device was used for experimental results of head motion and eye tracking and correlation with biomechanical model. A full Navier-Stokes equations and continuity equations are used for fluid domain with Arbitrary-Lagrangian Eulerian (ALE) formulation for mesh motion. Fluid-structure interaction for fluid coupling with cupula deformation is used. Particle tracking algorithm has been used for particle motion. Different size and number of particles with their full interaction between themselves, wall and cupula deformation are used. Velocity distribution, shear stress and force from endolymph side are presented for parametric one SCC and patient specific three SCC. All the models are used for correlation with the same experimental protocols with head moving and nystagmus eye tracking. A good correlation was found with numerical simulation of membrane deflection and nystagmus response detected with tracking technology. It can be used for virtual games with detection of vestibular disorders to the users.
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