局部光动力治疗背景下颌面部及颈部细胞局部免疫状态的研究

L. A. Cherniak, P. V. Harelik, M. V. Haretskaya, V. Sheibak
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摘要

目标。目的:探讨局部光动力治疗对颌面部及颈部痰疹患者局部免疫功能的影响。材料和方法。本研究包括62例颌面部及颈部的痰。患者分为两组。第一组患者按传统方法局部治疗。第二组患者在传统治疗措施复杂的基础上,加行局部PDT治疗。在Fotolon制剂局部PDT的影响下,我们观察到颌面部术后创面痰单瘤患者的吞噬功能激活,CD3 + t淋巴细胞群,CD4 + t辅助亚群,免疫调节指数(IRI)的增加,同时CD8 + t淋巴细胞水平下降,CD25+活化的t淋巴细胞和携带白细胞介素2受体的b淋巴细胞减少。CD95+激活携带fas受体的t淋巴细胞和b淋巴细胞,补体活性、循环免疫复合物(CIC)、IgM、IgA水平随igg升高而降低。局部PDT在颌面部和颈部痰病患者中激活局部免疫。暴露于PDT通过增加患者的先天免疫反应和术后伤口区域明显的免疫反应性,引起更平衡的免疫系统反应。
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State of local immune in phegmon of the maxillofacial region and neck on the background local photodynamic therapy
Objective. To study the effect of local photodynamic therapy (PDT) on local immunity in patients with maxillofacial region and neck phlegmonas.Materials and methods. The study included 62 patients with phlegmon of the maxillofacial region and neck. Two groups of patients were formed. Patients of the 1st group were treated locally according to the traditional methods. Patients of the second group additionally underwent local PDT on the background of the complex of traditional therapeutic measures.Results. Under the influence of local PDT with the preparation «Fotolon» in patients with maxillofacial region phlegmonomas in the postoperative wound we observed activation of phagocytosis, an increase in the population of CD3 + T-lymphocytes, subpopulation CD4 + T-helper, immunoregulatory index (IRI) with a simultaneous decrease in the level of CD8 + T-lymphocytes, The decrease of CD25+ activated Tand B-lymphocytes carrying the receptor for interleukin 2, and CD95+ activated Tand B-lymphocytes carrying the Fas-receptor, the decrease of complement activity, circulating immune complexes (CIC), IgM, IgA levels with an increase of IgG.Conclusion. Local PDT activates local immunity in patients with maxillofacial and neck phlegmons. Exposure to PDT causes a more balanced immune system response by increasing the innate immune response in patients and a pronounced immunological reactivity in the region of the postoperative wound.
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