超薄聚(n -异丙基丙烯酰胺)接枝到玻璃盖板卡瓦上的特性

Y. Akiyama, K. Fukumori, M. Yamato, K. Sakai, T. Okano
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摘要

超薄温度响应聚合物-聚n -异丙基丙烯酰胺(PIPAAm)接枝层在温度变化下表现出细胞附着和脱离的特性。这些性能取决于接枝PIPAAm的厚度和数量,并且可以在极薄的厚度下观察到(例如,组织培养聚苯乙烯的厚度为20 nm,玻璃盖片的厚度为5 nm)。虽然这一现象没有得到明确的证明,但我们提出了一种机制。也就是说,较薄的PIPAAm层受到基底表面附近的PIPAAm链的脱水。脱水作用逐渐促进接枝的PIPAAm链向最外层区域脱水。在本报告中,我们试图通过研究PIPAAm层厚度随温度的动态变化来证明所提出的机制。采用原子力显微镜(AFM)在高于和低于lst的水溶液条件下测量了这种变化。结果表明,在大气和水条件下,较薄的PIPAAm层厚度没有变化,而较厚的PIPAAm层厚度发生了变化。这一差异有力地支持了所提出的机制。
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Features of ultra thin poly(N-isopropylacrylamide) grafted onto glass cover slips
Ultra thin temperature responsive polymer, poly(N-isopropylacrylamide) (PIPAAm) grafted layer exhibits cell attachment and detachment properties in response to temperature change. Such properties are dependent on thickness and amount of the grafted PIPAAm, and are observed for extremely ultra thin thickness (for example, 20 nm thickness for tissue culture poly styrene and 5 nm for glass cover slips). Although this phenomenon was not demonstrated clearly, we have proposed a mechanism. Namely, thinner PIPAAm layer are subjected to dehydration of the PIPAAm chains in the vicinity of basal surfaces. The dehydration progressively promotes dehydration of the grafted PIPAAm chains toward to the outermost regions. In this presentation, we tried to demonstrate the proposed mechanism by investigating the dynamic alternation of thickness of PIPAAm layer in response to temperature. The alternation was measured undere aqueous conditions above and below LCST, using AFM. As a result, thickness of thinner PIPAAm layer was not altered between under atmospheric and aqueous conditions, while thicker layer was done. This difference strongly support the proposed mechanism.
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