GREEN CHEMICAL SYNTHESIS AND PROPERTIES OF SOLID DISPERSIONS OF BENZIMIDAZOLE –Β. NAPHTHOL BINARY DRUG SYSTEM

With a view to synthesize and characterize the enhanced pharmaceutical properties of the solid-liquid dispersions of binary drug system through a green chemical technique, the present communication have been undertaken for detailed investigation of thermodynamic and interfacial properties of benzimidazole (BI) and β. naphthol (βN) binary eutectic and non-eutectic drug dispersions. Eutectic solid dispersion was observed at 0.657-mole fraction of β. naphthol (βN) and at melting temperature 90°C. Thermodynamic quantities; Partial and Integral excess Gibbs energy (gE), excess enthalpy (hE), excess entropy (sE) of eutectic and non-eutectic dispersions were determined with the help of activity coefficient data. The negative deviation from ideal behaviour has been seen in the system which refers to a stronger association between unlike molecules during the formation of the binary mix. The negative value of Gibbs free energy of mixing (DGM) refers to the mixing for all eutectic and non-eutectic dispersions are spontaneous. The solid-liquid interfacial characteristics i.e., the entropy of fusion per unit volume (DSV), solid-liquid interfacial energy (s), roughness parameter (α), grain boundary energy and roughness parameter (α) of eutectic and non-eutectic solid dispersions have been reported. The size of the critical nucleus at different undercooling has been found in nanoscale, which may be a big significance in the pharmaceutical world. The value of roughness parameter, α > 2 was observed which manifests the faceted and irregular growth leads in the system.