Correlation between Haemoglobin Concentration and Malondialdehyde Level in Healthy Middle Age Adults

Background and Aims: In every disease, there will be the triggers on the occurrences. One of them is the oxidative stress, an imbalance between free radicals such as reactive oxygen species (ROS) and the antioxidants. The human body manages free radicals through neutralization by the antioxidative defense mechanism, however, when excessive free radicals being produced, it will become less effective. Over 40 years of age, oxidative stress become prominent and may associated with many diseases such as neural disorders and cardiovascular diseases. Oxidative stress can cause damage to lipids, known as lipid peroxidation, producing malondialdehyde (MDA), a marker to detect the degree of oxidative stress. Availability of oxygen (O2) is the main factor of the ROS formation, which could be indicated by haemoglobin (Hb) concentration. Thus, this research is conducted to find out the correlation between Hb concentration and MDA level in healthy middle age adults.Methods: A correlation study was conducted in a private University, Shah Alam from January 2018 until March 2018. Total 16 participants, who are MSU staffs, age between 45 and 65, with no known diseases, are selected after the consents are gained. Pearson correlation was used for statistical analysis of the data.Results: It is found that there is a strong correlation between Hb concentration and MDA level (r: .756, p <0.001). This means that MDA production is significantly increased when the Hb concentration is increased.Conclusion: The MDA level is strongly correlate with the Hb concentration in the middle age apparently healthy adults. It can be postulated that MDA production correlates with oxygen availability at the intracellular respiration in normal middle aged person