一种用于无线肠组织采集的新型活检胶囊内窥镜

Viet Ha Le, M. Hoang, Du Van Nguyen, Eunpyo Choi, ong-oh Park, Chang-sei Kim, Jayoung Kim, Byungjeon Kang
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引用次数: 2

摘要

本研究提出一种新的无线活检胶囊内镜方法。开发的活检内窥镜可以在调查过程中主动控制,并在可疑的目标病变处采集组织样本。新型胶囊内窥镜由永磁体、显微活检穿孔模块和外部电磁驱动系统组成。制作了一种直径为12mm、长为32mm的带活检装置胶囊型内窥镜样机。通过控制外部电磁驱动,实现胶囊内窥镜的定位运动和活检操作。电磁驱动系统的可控磁场与胶囊体内永磁体的相互作用,使微活检模块能够挤出胶囊体外进行组织采集操作。收集的活检组织体积约为5 mm3,足以进行组织学分析。在离体条件下,对活检模块的受力、可控性进行了测试。提供了运动、靶向和活检程序的可行性。
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A Novel Biopsy Capsule Endoscope for Wireless Intestinal Tissue Collection
A novel wireless biopsy capsule endoscopic method is presented in this study. The developed biopsy endoscope can be actively controlled during investigation process and collect tissue sample at suspicious target lesion. The novel capsule endoscope consists of a permanent magnet, a micro biopsy punch module, and an external electromagnetic actuation system. A pill-shape prototype of capsule endoscope with biopsy device is manufacture with dimension of 12 mm in diameter and 32 mm in length. By controlling the external electro-magnetic actuation, we can create the targeting locomotion and biopsy operation for capsule endoscope. The interactions between controllable magnetic field of electromagnetic actuation system and permanent magnet inside capsule body enables the micro-biopsy module be able to extrude out of capsule body for tissue collection operation. The collected biopsy tissue had volume of about 5 mm3, which is sufficient for histological analysis. Experiments are conducted to measure force, controllability of biopsy module in ex-vivo. The feasibility of locomotion, targeting and biopsy procedure are also provided.
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