Impact Of Grape Seed Extract On The Oral Cancer: A Systematic Review

Introduction : The oral cancer includes various kinds of malignant neoplasms developed in the mouth. The present study aims at applying the grape seed extract in dentistry (systematic review study). Materials and methods : In this systematic review study, the articles of databases of Google Scholar, PubMed and SCOPUS were searched within 2000-2020. All information was classified in a table. Results: In searching the [13] investigated the role of grape seed extract in treating the toxicity by radiotherapy and suggested that both types of extract (grape seed extract (GSE) and grape peel extract (GPE)) reduce the impacts of chemotherapy cytotoxicity or radiotherapy on the natural cells. In view of the various impacts of grape seed extract on dentistry, we investigated the impact of grape seed extract on the oral cancer in this systematic review study (Figure 1). animal studies confirm the impact of grape seed extract on treatment of oral cancer cells. Therefore, it is necessary to conduct the clinical trial studies in the field of use of the grape seed extract as the therapeutic supplement in treating the oral cancer.