{"title":"双氯芬酸钠对硫化氢过量和不足大鼠胃黏膜生化指标的影响","authors":"N. Voloshchuk, I. Taran, A. Melnik","doi":"10.15550/ASJ.2015.01.036","DOIUrl":null,"url":null,"abstract":"In this article the effect of diclofenac sodium on biochemical parameters of gastric mucosa against the background of deficit and excess of hydrogen sulfide in rats was investigated. It turned out that such NSAIDs increased the process of peroxidation of lipid and protein and caused an imbalance in the system of antioxidant, disturbed the phospholipid spectrum and reduced mucus production of glycosaminoglycans in stomach. Administration of diclofenac sodium against background of H 2S deficit is accompanied by an increasing of range of these changes in metabolic processes in gastric mucosa, while its use with H 2S donor normalizes the course of biochemical processes in gastric mucosa.","PeriodicalId":403624,"journal":{"name":"The Advanced Science Journal","volume":"46 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2015-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"INFLUENCE OF DICLOFENAC SODIUM ON BIOCHEMICAL INDICATORS OF STOMACH MUCOSA CONDITIONS AGAINST THE BACKGROUND OF EXCESS AND DEFICIENCY OF HYDROGEN SULFIDE IN RATS\",\"authors\":\"N. Voloshchuk, I. Taran, A. Melnik\",\"doi\":\"10.15550/ASJ.2015.01.036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this article the effect of diclofenac sodium on biochemical parameters of gastric mucosa against the background of deficit and excess of hydrogen sulfide in rats was investigated. It turned out that such NSAIDs increased the process of peroxidation of lipid and protein and caused an imbalance in the system of antioxidant, disturbed the phospholipid spectrum and reduced mucus production of glycosaminoglycans in stomach. Administration of diclofenac sodium against background of H 2S deficit is accompanied by an increasing of range of these changes in metabolic processes in gastric mucosa, while its use with H 2S donor normalizes the course of biochemical processes in gastric mucosa.\",\"PeriodicalId\":403624,\"journal\":{\"name\":\"The Advanced Science Journal\",\"volume\":\"46 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-02-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Advanced Science Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15550/ASJ.2015.01.036\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Advanced Science Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15550/ASJ.2015.01.036","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
INFLUENCE OF DICLOFENAC SODIUM ON BIOCHEMICAL INDICATORS OF STOMACH MUCOSA CONDITIONS AGAINST THE BACKGROUND OF EXCESS AND DEFICIENCY OF HYDROGEN SULFIDE IN RATS
In this article the effect of diclofenac sodium on biochemical parameters of gastric mucosa against the background of deficit and excess of hydrogen sulfide in rats was investigated. It turned out that such NSAIDs increased the process of peroxidation of lipid and protein and caused an imbalance in the system of antioxidant, disturbed the phospholipid spectrum and reduced mucus production of glycosaminoglycans in stomach. Administration of diclofenac sodium against background of H 2S deficit is accompanied by an increasing of range of these changes in metabolic processes in gastric mucosa, while its use with H 2S donor normalizes the course of biochemical processes in gastric mucosa.
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