Ginseng Malva Verticillata Tea (GMVT) Improve Glucose and Lipid Metabolism by Up-regulation of Leptin Hormone in Overweight Rats

ABSTRACT: Hyperglycemia plays a main role in the pathogenesis of cardiovascular diseases, fatty liver disease and insulin resistance in Diabetes mellitus type 2 (T2DM). Excess adipose tissue is the main risk factor for developing T2DM. Numerous drugs have been approved to reduce body weight and these medicines act by increasing lipolysis, decreasing satiety level, and increasing thermogenesis. But due to their adverse effects they are withdraw from the market. People are interested in using herbs and herbal drugs to achieve the best effect with fewer side effects. Traditionally in Asia, cinnamon (Cinnamomum verum), bitter gourd (Momordica charantia), dill (Anethum graveolens), black cumin (Nigella sativa). Turmeric, Ginger, green cardamom, Fenugreek and Ginseng use to improve hyperlipidemic and hypoglycemicconditions. In the current study, we treated overweight rats to ginseng tea. Results demonstrated a significant decrease in glucose, LDL-C, and cholesterol while increase in the HDL-C and leptin levels. Leptin is belonging to cytokine release from adipose tissue exhibit decrease satiety, increase energy expenditure and reduce fat by inhibiting lipogenesis and increasing lipolysis. Thus, it was concluded Ginseng Malva Verticillata tea (GMVT) can be suggested as a possible alternative treatment to improve lipid profile, hyperglycemia and related pathogeneses.