Human T-Lymphotropic Virus

We reported a rare case of HTLV-1-associated primary gastric lymphoma. A 65-year-old man admitted for epigastric discomfort was found in endoscopic examination and an upper gastrointestinal series to have an irregular elevated lesion in the middle third of the stomach, and histological study showed T-cell type lymphoma. Anti-HTLV-1 antibody was positive in serum. CT and galium scintigraphy showed no lymph node swelling or metastasis to other organs. We conducted total gastrectomy, splenectomy, and cholecystectomy with D2 lymph node dissection. HTLV-1 pro-viral DNA was positive in the resected specimen, but negative in bone marrow. Abnormal lymphocytes were negative in peripheral blood and bone marrow. We diagnosed this as a case of HTLV-1-associated primary gastric lymphoma, a very rare occurrence with no treatment strat-egy yet established. Further accumulation of cases should help solve this problem.