干细胞治疗及其在神经系统疾病中的应用综述

Omeshree Nagrale, M. Shoaib
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摘要

干细胞有能力在人体中构建各种类型的组织;因此,它们在组织再生和修复方面具有很大的潜力。为了使这些细胞符合“干细胞”的定义,它们必须表现出两个基本特征。首先,干细胞必须具有无限自我更新的能力,以产生与原始细胞完全相同的后代。其次,干细胞必须有能力分化成特化的成体细胞类型。干细胞以其独特和容易的潜力,为器官发育和组织修复提供了基础。再生疗法或干细胞疗法旨在“恢复”现有的故障细胞,通过来自外源性或内源性来源的新细胞重新填充器官,改变细胞外基质,或通过增强血管生成来增加血液供应。本文综述了目前干细胞生物学的概念、在神经系统疾病中的应用以及在各种人类疾病再生治疗中的重要进展和局限性。
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Stem Cell Therapy& Its Application in Neurological Conditions A Review
Stem cells have the ability to build every type of tissues in the human body; hence they have great potential for future therapeutic uses in tissue regeneration and repair. In order for these cells to fall under the definition of “ stem cells ”, they must display two essential characteristics. First, stem cells must have the ability of unlimited self-renewal to produce progeny exactly the same as the originating cells. Second, stem cells must have the ability to differentiate into a specialized adult cell type. Stem cells with their unique and facile potentialities, offer building blocks for organ development and tissue repair. Regenerative therapy or Stem cell therapy is aimed at ‘reviving’ existing malfunctioning cells, repopulating the organ by new cells from exogenous or endogenous sources, altering the extra-cellular matrix, or increasing blood supply by enhancing vasculogenesis. This review summarizes the current concepts in stem cell biology its application in neurological conditions and important advancements, limitations with respect to their prospective use in regeneration therapies in various human diseases.
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