单细胞超宽带电磁波谱的微流控装置

T. Akalin, S. Arscott, B. Bocquet, N. Bourzgui, V. Mille, V. Senez, A. Treizebré
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引用次数: 2

摘要

通过在宽频谱频率(DC-THz)上执行介电光谱,可以在没有标记过程的情况下进行单细胞分析。这就是为什么我们正在开发不同的微观结构,无论是平面/3D电极或传输线,以及使用BIOMEMS技术的微流体装置。在我们的设备中,硅或玻璃衬底与聚合物材料和金图案相结合。对于低频(LF)应用,PDMS已被选择,而对于高频(HF)结构,PPTMDSO是首选。我们正在设计器件,这要归功于使用COMSOL (LF)或CST (HF)软件进行建模和仿真。不同的设计已经制作,并在本文中提出。最后,我们对低频范围(<10 MHz)进行了单单元测量,下一步将重点放在高频测量上
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Microfluidic Devices for Ultra Wide Band Electromagnetic Spectroscopy of Single Cell
By performing dielectric spectroscopy across a wide spectrum of frequencies (DC-THz), single-cell analysis could be performed without labeling process. That is why we are developing different micro structures, either planar/3D electrodes or transmission lines, and microfluidic devices using BIOMEMS technologies. In our devices, silicon or glass substrates are combined with polymeric materials and gold patterns. For low frequency (LF) applications, PDMS has been chosen while for high frequency (HF) structures, the PPTMDSO is preferred. We are designing the devices thanks to modeling and simulation using either COMSOL (LF) or CST (HF) softwares. Different designs have already been fabricated and are presented in this paper. Finally, we have performed single cell measurements for the low frequency range (<10 MHz) and the next step will focuse on high frequency measurements
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