The use of correlation analysis for the evaluation of intersystemic immune-epyphyseal relationships in norm, under the disturbance of the light-regimen and the application of melatonin

The use of correlation analysis made it possible to characterize the relationship between the epiphysis — the central organ of regulation of circadian rhythms — and the immune system in various experimental situations: in mice of different lines and rats in conditions of disturbance of the light regime and the application of melatonin. Based on the increase of the number of correlation links between the parameters of the epiphysis and the immune system, as well as intraimmune connections, a conclusion has been made about a reduction in adaptive capacity and an increase in the intensity of the functioning of the immune system and the epiphyseal-immune complex at round-the-clock (all-day) illumination, which disrupts circadian rhythms and blocks the synthesis of melatonin in the pineal gland, and also in mice with a genetically determined melatonin synthesis deficiency. The results of correlation analysis led to the conclusion of the restoration of the relationship between the immune system and the pineal gland in a correction of desynchronosis by melatonin.