{"title":"人诱导多能干细胞衍生内皮细胞模拟内皮功能障碍","authors":"Bing-Li Liu, J. Ma, L. Ye","doi":"10.15761/vdt.1000164","DOIUrl":null,"url":null,"abstract":"Human induced pluripotent stem cells (hiPSCs) cells are a type of cells derived from human somatic cells that are reprogrammed to an embryonic stem cell (ESC)–like pluripotent state. hiPSCs are being explored as disease modelling and drug discovery for diabetes mellitus. Modelling endothelial dysfunction using endothelail cells (ECs) derived from diabetic hiPSCs has the potential for evaluating the therapeutic effect of drugs or chemicals on endothelial dysfunction and for understanding the cross-talk between ECs and inflammatory cells or cytokines which will benefit the development of new therapeutic strategies for treatment of cardiovascular diseases. of","PeriodicalId":206117,"journal":{"name":"Vascular Diseases and Therapeutics","volume":"9 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Human Induced Pluripotent Stem Cell–Derived Endothelial Cells for Modelling of Endothelial Dysfunction\",\"authors\":\"Bing-Li Liu, J. Ma, L. Ye\",\"doi\":\"10.15761/vdt.1000164\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Human induced pluripotent stem cells (hiPSCs) cells are a type of cells derived from human somatic cells that are reprogrammed to an embryonic stem cell (ESC)–like pluripotent state. hiPSCs are being explored as disease modelling and drug discovery for diabetes mellitus. Modelling endothelial dysfunction using endothelail cells (ECs) derived from diabetic hiPSCs has the potential for evaluating the therapeutic effect of drugs or chemicals on endothelial dysfunction and for understanding the cross-talk between ECs and inflammatory cells or cytokines which will benefit the development of new therapeutic strategies for treatment of cardiovascular diseases. of\",\"PeriodicalId\":206117,\"journal\":{\"name\":\"Vascular Diseases and Therapeutics\",\"volume\":\"9 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Vascular Diseases and Therapeutics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15761/vdt.1000164\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vascular Diseases and Therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15761/vdt.1000164","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Human Induced Pluripotent Stem Cell–Derived Endothelial Cells for Modelling of Endothelial Dysfunction
Human induced pluripotent stem cells (hiPSCs) cells are a type of cells derived from human somatic cells that are reprogrammed to an embryonic stem cell (ESC)–like pluripotent state. hiPSCs are being explored as disease modelling and drug discovery for diabetes mellitus. Modelling endothelial dysfunction using endothelail cells (ECs) derived from diabetic hiPSCs has the potential for evaluating the therapeutic effect of drugs or chemicals on endothelial dysfunction and for understanding the cross-talk between ECs and inflammatory cells or cytokines which will benefit the development of new therapeutic strategies for treatment of cardiovascular diseases. of
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