F. Kasashima, S. Kasashima, A. Kawashima, Y. Matsumoto, Yoshitaka Yamamoto
Objective : Approximately half of inflammatory abdominal aortic aneurysms, defined by the prominent thickening adventitia, are immunoglobulin G4 (IgG4)- related diseases characterized by elevated serum IgG4 and IgG4-positive-plasmacytes infiltration. IgG4-related AAAs (IgG4-AAAs) exhibit vasculitis with elevated inflammatory marker levels. Matrix metalloproteinases (MMPs) degrade the extracellular matrix to destroy the aortic structures to progress aneurysm. This report examined pre- and postoperative serum MMPs and inflammatory marker levels to evaluate the prognosis of IgG4-AAAs after endovascular aortic repair (EVAR). Methods : Among 25 patient with inflammatory abdominal aortic aneurysms (>2-mm-thick periaortic fibrosis) treated with EVAR, IgG4-AAA was diagnosed in 14 patients, and the remaining 11 patients were classified as non-IgG4-AAA. IgG4-AAAs were categorized into cases with increased (IgG4-AAA-up; n = 6) or decreased (IgG4-AAA-down; n=8) postoperative serum IgG4 levels. Before EVAR and after 24 months, we compared the serum MMP, inflammatory marker levels, periaortic fibrosis, and aneurysm diameter. Results : IgG4-AAAs patients showed higher preoperative IL-6 levels, increased postoperative MMP-9 levels, and enlarged postoperative aneurysmal diameters compared with non-IgG4-AAA patients. Among IgG4-AAAs, IgG4-AAA-up exhibited higher preoperative MMP-9, higher preoperative monocytes and eosinophils, increased postoperative MMP-9 and IL-6, and larger aneurysm diameter than IgG4-AAA-down. All patients in IgG4-AAA-down showed shrunk preoperative aneurysm, although almost all patients in IgG4-AAA-up showed enlarged. In IgG4-AAA-up, IgG4/IgG ratio was significantly higher consistently before and after EVAR. MMP-9 was significantly correlated with IgG4 and IL-6. MMP-2 was not significantly different between patients with and without as well as between IgG4-AAA-up and IgG4-AAA-down. Conclusion: Increased postoperative MMP-9 and IL-6 in IgG4-AAA may accelerate aneurysmal progression after EVAR. IgG4-AAA-up exhibited increased IL-6 levels and larger aneurysm diameters following EVAR than IgG4-AAA-down and were considered as the high-risk group with a tendency toward progression. Before surgery, a high IgG4/IgG ratio, high MMP-9 concentrations, a high ratio of monocytes and eosinophils might predict IgG4-AAA-up.
{"title":"Predictors of the progression of immunoglobulin-G4-related abdominal aortic aneurysms after endovascular therapy","authors":"F. Kasashima, S. Kasashima, A. Kawashima, Y. Matsumoto, Yoshitaka Yamamoto","doi":"10.15761/VDT.1000177","DOIUrl":"https://doi.org/10.15761/VDT.1000177","url":null,"abstract":"Objective : Approximately half of inflammatory abdominal aortic aneurysms, defined by the prominent thickening adventitia, are immunoglobulin G4 (IgG4)- related diseases characterized by elevated serum IgG4 and IgG4-positive-plasmacytes infiltration. IgG4-related AAAs (IgG4-AAAs) exhibit vasculitis with elevated inflammatory marker levels. Matrix metalloproteinases (MMPs) degrade the extracellular matrix to destroy the aortic structures to progress aneurysm. This report examined pre- and postoperative serum MMPs and inflammatory marker levels to evaluate the prognosis of IgG4-AAAs after endovascular aortic repair (EVAR). Methods : Among 25 patient with inflammatory abdominal aortic aneurysms (>2-mm-thick periaortic fibrosis) treated with EVAR, IgG4-AAA was diagnosed in 14 patients, and the remaining 11 patients were classified as non-IgG4-AAA. IgG4-AAAs were categorized into cases with increased (IgG4-AAA-up; n = 6) or decreased (IgG4-AAA-down; n=8) postoperative serum IgG4 levels. Before EVAR and after 24 months, we compared the serum MMP, inflammatory marker levels, periaortic fibrosis, and aneurysm diameter. Results : IgG4-AAAs patients showed higher preoperative IL-6 levels, increased postoperative MMP-9 levels, and enlarged postoperative aneurysmal diameters compared with non-IgG4-AAA patients. Among IgG4-AAAs, IgG4-AAA-up exhibited higher preoperative MMP-9, higher preoperative monocytes and eosinophils, increased postoperative MMP-9 and IL-6, and larger aneurysm diameter than IgG4-AAA-down. All patients in IgG4-AAA-down showed shrunk preoperative aneurysm, although almost all patients in IgG4-AAA-up showed enlarged. In IgG4-AAA-up, IgG4/IgG ratio was significantly higher consistently before and after EVAR. MMP-9 was significantly correlated with IgG4 and IL-6. MMP-2 was not significantly different between patients with and without as well as between IgG4-AAA-up and IgG4-AAA-down. Conclusion: Increased postoperative MMP-9 and IL-6 in IgG4-AAA may accelerate aneurysmal progression after EVAR. IgG4-AAA-up exhibited increased IL-6 levels and larger aneurysm diameters following EVAR than IgG4-AAA-down and were considered as the high-risk group with a tendency toward progression. Before surgery, a high IgG4/IgG ratio, high MMP-9 concentrations, a high ratio of monocytes and eosinophils might predict IgG4-AAA-up.","PeriodicalId":206117,"journal":{"name":"Vascular Diseases and Therapeutics","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126837828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. di Maro, T. Mastantuono, M. Chiurazzi, Michela Caporrino, L. Battiloro, R. Scuri, A. Colantuoni, D. Lapi
Background/Objective: Myricetin, a flavonoid compound, is widely diffused in vegetables, fruits and beverages, well known for its antioxidant and anti-inflammatory properties. The present study was aimed to investigate the acute effects of myricetin on the pial microvascular alterations and oxygen-derived free radical formation, due to 30 min cerebral blood flow lowering (CBFL) and subsequent cerebral blood flow resumption (CBFR). Methods: Rat pial microvasculature was investigated using fluorescence microscopy through a closed cranial window. At first, arterioles were classified according to the Strahler’s ordering scheme. Then, arteriolar diameter, permeability increase, leukocyte adhesion to venular walls, perfused capillary length (CPL) and red blood cell velocity (VRBC) were quantified by computerized methods. Finally, reactive oxygen species (ROS) production was investigated in vivo by 2 ′ -7 ′ -dichlorofluorescein- diacetate assay and infarct size by 2,3,5-triphenyltetrazolium chloride staining. Results: After 30 min CBFL and 60 min CBFR, a decrease of arteriolar diameter, CPL and VRBC was detected; furthermore, increases in microvascular leakage and leukocyte adhesion were observed in hypoperfused animals. Conversely, myricetin administration induced dose-related arteriolar dilation, reduction in microvascular permeability as well as leukocyte adhesion when compared to those detected in bilateral common carotid artery occlusion-submitted animals; moreover, CPL and VRBC were preserved. In animals treated with myricetin the ROS production was blunted and infarct size significantly reduced. Conclusion: In conclusion, myricetin acute administration showed dose-related protective effects on rat pial microcirculation during CBFL and subsequent CBFR, inducing arteriolar dilation and inhibiting ROS formation, consequently preserving the blood brain barrier integrity.
{"title":"Myricetin preserves rat pial microcirculation from injury induced by cerebral hypoperfusion and reperfusion","authors":"M. di Maro, T. Mastantuono, M. Chiurazzi, Michela Caporrino, L. Battiloro, R. Scuri, A. Colantuoni, D. Lapi","doi":"10.15761/vdt.1000169","DOIUrl":"https://doi.org/10.15761/vdt.1000169","url":null,"abstract":"Background/Objective: Myricetin, a flavonoid compound, is widely diffused in vegetables, fruits and beverages, well known for its antioxidant and anti-inflammatory properties. The present study was aimed to investigate the acute effects of myricetin on the pial microvascular alterations and oxygen-derived free radical formation, due to 30 min cerebral blood flow lowering (CBFL) and subsequent cerebral blood flow resumption (CBFR). Methods: Rat pial microvasculature was investigated using fluorescence microscopy through a closed cranial window. At first, arterioles were classified according to the Strahler’s ordering scheme. Then, arteriolar diameter, permeability increase, leukocyte adhesion to venular walls, perfused capillary length (CPL) and red blood cell velocity (VRBC) were quantified by computerized methods. Finally, reactive oxygen species (ROS) production was investigated in vivo by 2 ′ -7 ′ -dichlorofluorescein- diacetate assay and infarct size by 2,3,5-triphenyltetrazolium chloride staining. Results: After 30 min CBFL and 60 min CBFR, a decrease of arteriolar diameter, CPL and VRBC was detected; furthermore, increases in microvascular leakage and leukocyte adhesion were observed in hypoperfused animals. Conversely, myricetin administration induced dose-related arteriolar dilation, reduction in microvascular permeability as well as leukocyte adhesion when compared to those detected in bilateral common carotid artery occlusion-submitted animals; moreover, CPL and VRBC were preserved. In animals treated with myricetin the ROS production was blunted and infarct size significantly reduced. Conclusion: In conclusion, myricetin acute administration showed dose-related protective effects on rat pial microcirculation during CBFL and subsequent CBFR, inducing arteriolar dilation and inhibiting ROS formation, consequently preserving the blood brain barrier integrity.","PeriodicalId":206117,"journal":{"name":"Vascular Diseases and Therapeutics","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130702998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Marion, E. Takahashi, Newton B. Neidert, Melissa Neisen, W. Harmsen, S. Misra
Purpose: The goals of this research were to compare tilt and caval penetration rates of the Günther Tulip (Cook Medical, Bloomington, IN) and Greenfield (Boston Scientific, Marlborough, MA) inferior vena cava (IVC) filters, and assess the difficulty of Tulip retrieval based on filter tilt, dwell time and caval wall penetration. Methods: Institutional review board approval was granted for this study, IRB #18-003517. Informed consent was waived by the institutional review board. This retrospective study reviewed Greenfield filter placement (n=26) and Tulip filter (n=203) removal. The electronic medical record was reviewed and a single author determined filter angle and caval penetration on the most recent available CT or catheter venogram. Filters removed with a snare were analyzed as routine removal and filters requiring additional devices or procedures were placed in a difficult removal group. Results: Greenfield filters had longer dwell time with a mean ± standard deviation of 811.3 ± 1398.1 days compared to 183.8 ± 262.1 days for Tulip filters (p=0.845). Filter tilt angle was not significantly different between the filter types 7.2 ± 4.7 for Greenfield filters and 5.5 ± 4.8 degrees for Tulip filters (p=0.09). Four (15.4%) Greenfield filters and 47 (23.2%) Tulip filters penetrated the caval wall >3 mm (P=0.37). Of the Tulip filters, those in the difficult removal group had a mean tilt of 7.6 ± 6.5 degrees compared to 4.6 ± 3.6 degrees in the routine removal group (p=0.0057). Conclusion: Greenfield IVC filters with longer dwell times demonstrate similar degrees of filter tilt and caval penetration as Tulip filters. A mean tilt of 7.6 ± 6.5 degrees indicates a filter which may require additional or alternative techniques for removal. *Correspondence to: Misra S, MD, FSIR FAHA, Professor of Radiology, Mayo Clinic, Department of Radiology, 200 First Street SW, Rochester, MN 55905, USA, Tel: 507-255-7208; Fax: 507-255-7872; E-mail: misra.sanjay@mayo.edu Received: November 04, 2019; Accepted: November 15, 2019; Published: November 18, 2019 Introduction Inferior vena cava (IVC) filters are commonly placed in patients at risk for pulmonary embolism (PE) or who have PE and a contraindication to anticoagulation, have failed anticoagulation, or have had a complication related to anticoagulation [1]. Over the past several decades, there have been numerous iterations to the IVC filter design and conically-shaped IVC filters are currently the most commonly used type of filter [2]. Permanent filters have largely been replaced by retrievable filters due to increased risk of lower extremity thrombosis associated with prolonged permanent filter dwell time [1,3,4]. Filter-related complications include caval wall penetration, IVC thrombosis, and in some cases, retrievable filters cannot be safely removed due to hook contact with the caval wall or strut penetration through the cava [1,5-7]. These issues tend to be magnified by the degree of filter tilt and duration
目的:本研究的目的是比较g nther Tulip (Cook Medical, Bloomington, IN)和Greenfield (Boston Scientific, Marlborough, MA)下腔静脉(IVC)滤器的倾斜和下腔静脉穿透率，并根据滤器倾斜、停留时间和下腔静脉壁穿透率评估Tulip检索的难度。方法:机构审查委员会批准了本研究，IRB #18-003517。机构审查委员会放弃了知情同意。本回顾性研究回顾了Greenfield过滤器放置(n=26)和Tulip过滤器去除(n=203)。我们回顾了电子病历，并在最近可用的CT或导管静脉图上确定了滤过器角度和腔静脉穿透。用诱捕器去除的过滤器被分析为常规去除，需要额外设备或程序的过滤器被放置在困难去除组。结果:Greenfield滤光片的停留时间比Tulip滤光片的停留时间长，平均±标准差为811.3±1398.1 d (p=0.845);两种滤镜倾角差异无统计学意义，Greenfield滤镜为7.2±4.7度，Tulip滤镜为5.5±4.8度(p=0.09)。4个(15.4%)Greenfield滤过器和47个(23.2%)Tulip滤过器穿透腔壁>3 mm (P=0.37)。在Tulip过滤器中，困难去除组的平均倾斜度为7.6±6.5度，而常规去除组为4.6±3.6度(p=0.0057)。结论:Greenfield滤膜与Tulip滤膜具有相似的滤膜倾斜度和下腔穿透度。平均倾斜度为7.6±6.5度表明该过滤器可能需要额外或替代技术来去除。*通讯:Misra S, MD, FSIR FAHA，梅奥诊所放射科教授，200 First Street SW, Rochester, MN 55905, USA，电话:507-255-7208;传真:507-255-7872;邮箱:misra.sanjay@mayo.edu收稿日期:2019年11月04日;录用日期:2019年11月15日;下腔静脉(IVC)过滤器通常用于有肺栓塞(PE)风险或有PE和抗凝禁忌症、抗凝失败或有抗凝相关并发症的患者[1]。在过去的几十年里，IVC滤波器的设计经历了多次迭代，锥形IVC滤波器是目前最常用的滤波器类型[2]。由于永久性过滤器停留时间延长会增加下肢血栓形成的风险，永久性过滤器已在很大程度上被可回收过滤器所取代[1,3,4]。滤器相关并发症包括腔静脉壁穿透、下腔静脉血栓形成，在某些情况下，由于钩状接触腔静脉壁或支撑穿透腔静脉，可回收滤器无法安全取出[1,5-7]。这些问题往往会被过滤器倾斜的程度和停留时间的持续时间放大[8]。尽管永久性过滤器和可回收过滤器之间存在类似的潜在并发症，但永久性过滤器与设备相关的并发症较少[7,9]。本研究的目的是比较相似的锥形永久性Greenfield (Boston Scientific, Marlborough, MA)滤器和可回收g nther Tulip (Cook Medical, Bloomington, IN)滤器的IVC滤器倾斜和下腔渗透率，并评估倾斜和渗透对Tulip滤器可回收性的影响。方法本研究获得机构审查委员会批准，采用回顾性审查，研究符合《健康保险流通与责任法案》。机构审查委员会放弃了知情同意。
{"title":"Tilt and caval penetration among permanent and retrievable inferior vena cava filters of similar design","authors":"J. Marion, E. Takahashi, Newton B. Neidert, Melissa Neisen, W. Harmsen, S. Misra","doi":"10.15761/vdt.1000171","DOIUrl":"https://doi.org/10.15761/vdt.1000171","url":null,"abstract":"Purpose: The goals of this research were to compare tilt and caval penetration rates of the Günther Tulip (Cook Medical, Bloomington, IN) and Greenfield (Boston Scientific, Marlborough, MA) inferior vena cava (IVC) filters, and assess the difficulty of Tulip retrieval based on filter tilt, dwell time and caval wall penetration. Methods: Institutional review board approval was granted for this study, IRB #18-003517. Informed consent was waived by the institutional review board. This retrospective study reviewed Greenfield filter placement (n=26) and Tulip filter (n=203) removal. The electronic medical record was reviewed and a single author determined filter angle and caval penetration on the most recent available CT or catheter venogram. Filters removed with a snare were analyzed as routine removal and filters requiring additional devices or procedures were placed in a difficult removal group. Results: Greenfield filters had longer dwell time with a mean ± standard deviation of 811.3 ± 1398.1 days compared to 183.8 ± 262.1 days for Tulip filters (p=0.845). Filter tilt angle was not significantly different between the filter types 7.2 ± 4.7 for Greenfield filters and 5.5 ± 4.8 degrees for Tulip filters (p=0.09). Four (15.4%) Greenfield filters and 47 (23.2%) Tulip filters penetrated the caval wall >3 mm (P=0.37). Of the Tulip filters, those in the difficult removal group had a mean tilt of 7.6 ± 6.5 degrees compared to 4.6 ± 3.6 degrees in the routine removal group (p=0.0057). Conclusion: Greenfield IVC filters with longer dwell times demonstrate similar degrees of filter tilt and caval penetration as Tulip filters. A mean tilt of 7.6 ± 6.5 degrees indicates a filter which may require additional or alternative techniques for removal. *Correspondence to: Misra S, MD, FSIR FAHA, Professor of Radiology, Mayo Clinic, Department of Radiology, 200 First Street SW, Rochester, MN 55905, USA, Tel: 507-255-7208; Fax: 507-255-7872; E-mail: misra.sanjay@mayo.edu Received: November 04, 2019; Accepted: November 15, 2019; Published: November 18, 2019 Introduction Inferior vena cava (IVC) filters are commonly placed in patients at risk for pulmonary embolism (PE) or who have PE and a contraindication to anticoagulation, have failed anticoagulation, or have had a complication related to anticoagulation [1]. Over the past several decades, there have been numerous iterations to the IVC filter design and conically-shaped IVC filters are currently the most commonly used type of filter [2]. Permanent filters have largely been replaced by retrievable filters due to increased risk of lower extremity thrombosis associated with prolonged permanent filter dwell time [1,3,4]. Filter-related complications include caval wall penetration, IVC thrombosis, and in some cases, retrievable filters cannot be safely removed due to hook contact with the caval wall or strut penetration through the cava [1,5-7]. These issues tend to be magnified by the degree of filter tilt and duration ","PeriodicalId":206117,"journal":{"name":"Vascular Diseases and Therapeutics","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125841138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: Depression is prevalent among stroke survivors and is associated with a number of adverse health outcomes. However, for those with severe depression after chronic stroke, there is little to no information regarding response of depression to exercise addressing persistent physical impairments and dysfunction or response to exercise therapy for those who are severely depressed. Methods: We enrolled a male stroke survivor at 1.75 years post stroke, with severe depression. Measures collected at preand post-treatment were as follows: Beck Depression (mood); Fugl-Meyer (FM joint movement coordination); Berg Balance Scale (BBS); Timed Up and Go (TUG; mobility); Functional Independence Measure (FIM; subscales of Self-Care, Transfer, Locomotion); Craig Handicap Assessment and Reporting Technique (CHART; quality of life assessment of how patients with disabilities function in the community and at home); 36-Item Short Form Survey (SF36; quality of life measure); and the Stroke Impact Scale (SIS; stroke-specific quality of life measure). Exercise was scheduled as follows: 6mo therapy, five times/wk (1–2.5hrs/session); and additional 6mo, 2-3timeswk, and included aerobic exercise and coordination/strength training for balance and gait. The treatment protocol included exercises for balance and coordination of the lower limb, strengthening, gait coordination, and aerobics exercise on a stationary cycle. Results: Depression improved from severe to mild. The initial presence of severe depression did not preclude significant improvement in mobility and life role participation. Clinically significant gains were exhibited, not only in depression, but also in balance, mobility, and activities of daily living. Moreover, his quantified changes included clinically significant progression to categories of ‘low fall risk’ and ‘functionally independent’. He achieved important clinical and functional goals, as reflected by improved scores in measures of life role participation and personal milestones. Conclusion: Though this is a case study, it is reasonable to consider that a long-duration exercise program can be of great benefit in terms of functional and quality of life gains, regardless of the initial presence of severe depression. *Correspondence to: Daly JJ, Ph.D., Professor, Department of Neurology, College of Medicine, University of Florida, Director, Brain Rehabilitation Research Center, North Florida/South Georgia VA Medical Center, Florida, Tel: 1-216-402-8940; E-mail: janis.daly@neurology.ufl.edu
{"title":"Functional recovery and depression mitigation in a case study of chronic stroke receiving intensive, long-duration mobility/fitness training","authors":"Catherine Boissoneault, A. Khanna, J. Daly","doi":"10.15761/vdt.1000160","DOIUrl":"https://doi.org/10.15761/vdt.1000160","url":null,"abstract":"Purpose: Depression is prevalent among stroke survivors and is associated with a number of adverse health outcomes. However, for those with severe depression after chronic stroke, there is little to no information regarding response of depression to exercise addressing persistent physical impairments and dysfunction or response to exercise therapy for those who are severely depressed. Methods: We enrolled a male stroke survivor at 1.75 years post stroke, with severe depression. Measures collected at preand post-treatment were as follows: Beck Depression (mood); Fugl-Meyer (FM joint movement coordination); Berg Balance Scale (BBS); Timed Up and Go (TUG; mobility); Functional Independence Measure (FIM; subscales of Self-Care, Transfer, Locomotion); Craig Handicap Assessment and Reporting Technique (CHART; quality of life assessment of how patients with disabilities function in the community and at home); 36-Item Short Form Survey (SF36; quality of life measure); and the Stroke Impact Scale (SIS; stroke-specific quality of life measure). Exercise was scheduled as follows: 6mo therapy, five times/wk (1–2.5hrs/session); and additional 6mo, 2-3timeswk, and included aerobic exercise and coordination/strength training for balance and gait. The treatment protocol included exercises for balance and coordination of the lower limb, strengthening, gait coordination, and aerobics exercise on a stationary cycle. Results: Depression improved from severe to mild. The initial presence of severe depression did not preclude significant improvement in mobility and life role participation. Clinically significant gains were exhibited, not only in depression, but also in balance, mobility, and activities of daily living. Moreover, his quantified changes included clinically significant progression to categories of ‘low fall risk’ and ‘functionally independent’. He achieved important clinical and functional goals, as reflected by improved scores in measures of life role participation and personal milestones. Conclusion: Though this is a case study, it is reasonable to consider that a long-duration exercise program can be of great benefit in terms of functional and quality of life gains, regardless of the initial presence of severe depression. *Correspondence to: Daly JJ, Ph.D., Professor, Department of Neurology, College of Medicine, University of Florida, Director, Brain Rehabilitation Research Center, North Florida/South Georgia VA Medical Center, Florida, Tel: 1-216-402-8940; E-mail: janis.daly@neurology.ufl.edu","PeriodicalId":206117,"journal":{"name":"Vascular Diseases and Therapeutics","volume":"282 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123310472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radiofrequency and endovenous laser ablation (RFA/EVLA) are two of the most popular minimally invasive treatments and having come to the market earlier, they have a well-established safety record and are the current gold standard for comparison. Recent unrivalled 15-year follow-up data using RFA have shown excellent durable longterm technical success [1]. However, there are still significant adverse events and the concerns of skin burns and endovenous heat induced thrombosis (EHIT) (3-5%) [2,3] are unique to these thermal techniques.
{"title":"Cyanoacrylate glue using the VenaSeal™ Closure System for varicose veins may not be the panacea endovenous ablation device-more complications than you think","authors":"C. Keohane, Walsh, A. Tiwari, Davies Ah, Tang Ty","doi":"10.15761/VDT.1000184","DOIUrl":"https://doi.org/10.15761/VDT.1000184","url":null,"abstract":"Radiofrequency and endovenous laser ablation (RFA/EVLA) are two of the most popular minimally invasive treatments and having come to the market earlier, they have a well-established safety record and are the current gold standard for comparison. Recent unrivalled 15-year follow-up data using RFA have shown excellent durable longterm technical success [1]. However, there are still significant adverse events and the concerns of skin burns and endovenous heat induced thrombosis (EHIT) (3-5%) [2,3] are unique to these thermal techniques.","PeriodicalId":206117,"journal":{"name":"Vascular Diseases and Therapeutics","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130431893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human induced pluripotent stem cells (hiPSCs) cells are a type of cells derived from human somatic cells that are reprogrammed to an embryonic stem cell (ESC)–like pluripotent state. hiPSCs are being explored as disease modelling and drug discovery for diabetes mellitus. Modelling endothelial dysfunction using endothelail cells (ECs) derived from diabetic hiPSCs has the potential for evaluating the therapeutic effect of drugs or chemicals on endothelial dysfunction and for understanding the cross-talk between ECs and inflammatory cells or cytokines which will benefit the development of new therapeutic strategies for treatment of cardiovascular diseases. of
{"title":"Human Induced Pluripotent Stem Cell–Derived Endothelial Cells for Modelling of Endothelial Dysfunction","authors":"Bing-Li Liu, J. Ma, L. Ye","doi":"10.15761/vdt.1000164","DOIUrl":"https://doi.org/10.15761/vdt.1000164","url":null,"abstract":"Human induced pluripotent stem cells (hiPSCs) cells are a type of cells derived from human somatic cells that are reprogrammed to an embryonic stem cell (ESC)–like pluripotent state. hiPSCs are being explored as disease modelling and drug discovery for diabetes mellitus. Modelling endothelial dysfunction using endothelail cells (ECs) derived from diabetic hiPSCs has the potential for evaluating the therapeutic effect of drugs or chemicals on endothelial dysfunction and for understanding the cross-talk between ECs and inflammatory cells or cytokines which will benefit the development of new therapeutic strategies for treatment of cardiovascular diseases. of","PeriodicalId":206117,"journal":{"name":"Vascular Diseases and Therapeutics","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124003374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Berlanga-Acosta, J. Fernández-Montequín, Héctor Santana-Milián, Calixto Valdés-Pérez, William Savigne-Gutiérrez, Y. Mendoza-Marí, Ariana García-Ojalvo, Lisette Ponce de León Pérez, Yanisbel Ortiz Peña, O. Reyes Acosta, Nora Ventosa-Rull, L. Ferrer-Tasies, E. Martinez-Diaz, Luís Herrera-Martínez, G. Guillén-Nieto
{"title":"A narrative review on Epidermal Growth Factor (EGF) intralesional infiltrations for diabetic complex wounds: The rational of an innovative delivery route","authors":"J. Berlanga-Acosta, J. Fernández-Montequín, Héctor Santana-Milián, Calixto Valdés-Pérez, William Savigne-Gutiérrez, Y. Mendoza-Marí, Ariana García-Ojalvo, Lisette Ponce de León Pérez, Yanisbel Ortiz Peña, O. Reyes Acosta, Nora Ventosa-Rull, L. Ferrer-Tasies, E. Martinez-Diaz, Luís Herrera-Martínez, G. Guillén-Nieto","doi":"10.15761/vdt.1000191","DOIUrl":"https://doi.org/10.15761/vdt.1000191","url":null,"abstract":"","PeriodicalId":206117,"journal":{"name":"Vascular Diseases and Therapeutics","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126765544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 31 year old man patient presented by dyspnea for one month, no past history of heart disease had been noted. Physical examination detected 3rd gallop sound, sinus tachycardia and LVH were revealed on his ECG. Chest X ray showed a cardiomegaly with enlarged LV arch. Routine 2DTTE demonstrated enlarged LV and severely reduced EF. 2DTTE completed by 3DTTE visualized a LV myxoma that was attached to the posterior IVS next to apical area, hypermobile, pedunculated and excrescential. The risk of embolic events is very high. Regarding the severe heart failure, patient was followed up with medical treatment of heart failure and anticoagulant use
{"title":"LV myxoma on Real-time 3DTTE in a young patient with dilated cardiomyopathy and apical thrombus","authors":"Nguyen Tuan Vu","doi":"10.15761/vdt.1000183","DOIUrl":"https://doi.org/10.15761/vdt.1000183","url":null,"abstract":"A 31 year old man patient presented by dyspnea for one month, no past history of heart disease had been noted. Physical examination detected 3rd gallop sound, sinus tachycardia and LVH were revealed on his ECG. Chest X ray showed a cardiomegaly with enlarged LV arch. Routine 2DTTE demonstrated enlarged LV and severely reduced EF. 2DTTE completed by 3DTTE visualized a LV myxoma that was attached to the posterior IVS next to apical area, hypermobile, pedunculated and excrescential. The risk of embolic events is very high. Regarding the severe heart failure, patient was followed up with medical treatment of heart failure and anticoagulant use","PeriodicalId":206117,"journal":{"name":"Vascular Diseases and Therapeutics","volume":"2001 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125747862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Moxifloxacin induced abnormal behavior in a patient on hemodialysis to fracture central venous catheter: a case report","authors":"Yingjie Duan, Qingsong Wan, Zhangxiu He","doi":"10.15761/vdt.1000194","DOIUrl":"https://doi.org/10.15761/vdt.1000194","url":null,"abstract":"","PeriodicalId":206117,"journal":{"name":"Vascular Diseases and Therapeutics","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114266647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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