髓磷脂降解高分辨率成像的双折射显微镜设计和样品制备

Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN) Pub Date : 1900-01-01 DOI:10.1364/brain.2023.bw1b.5

Alexander J. Gray, Nathan Blanke, Rhiannon E Robinson, D. Rosene, I. Bigio

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摘要

髓磷脂的结构成像对神经系统疾病中大脑病理变化的表征至关重要。双折射显微镜用于亚微米(<300nm)分辨率下髓磷脂结构变化的快速可视化。

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Birefringence Microscope Design and Sample Preparation Exigencies for High-resolution Imaging of Myelin Degradation

Structural imaging of myelin is of utmost importance for characterization of pathological changes to the brain in neurological disorders. Birefringence microscopy is used for rapid visualization of structural changes to myelin at sub-micron (<300nm) resolution.

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Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN)

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