神经元温度依赖模型的稳定性分析

A. Ghajarjazy, Kanaan Mousaie, S. Sabzpoushan
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引用次数: 0

摘要

神经振荡发生在许多神经疾病中,如帕金森或癫痫,这使得研究抑制这些振荡的方法变得重要。不同系统行为的稳定性分析对于理解细胞建模的动力学机制起着至关重要的作用。本文采用数学方法研究了钾能态电压(VK)和温度(T)的影响,分析了多参数变化下修正的霍奇金-赫胥利模型的稳定性和分岔性。将(VK, T)平面划分为表示稳定和不稳定行为的两个区域。数值仿真验证了分析的有效性。这一结果可能有助于研究温度对病变细胞的刺激作用。
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Stability Analysis in a Temperature-Dependent Model of Neurons
Neural oscillation occurs in many neural disorders such as Parkinson or epilepsy, that makes it important to study methods to suppress these oscillations. Stability analysis of different system behaviors can play a crucial role in understanding dynamical mechanisms in cell modelling. In this study, mathematical method is used to investigate the effect of potassium Nernst Voltage (VK) and temperature (T). In this regard, we analyze the stability and bifurcations of a modified version of Hodgkin-Huxley model by changing multi parameters. The (VK, T) plane is partitioned into two regions which indicates stable and unstable behaviors. Numerical simulations illustrate the validity of the analysis. The results could be helpful in studying temperature stimulation of diseased cells.
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