V. Voitsitsky, V. Lebedeva, O. A. Tkachuk, I. V. Skuridina
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引用次数: 0
摘要
俄罗斯和全世界的肿瘤病理发病率正在稳步增长，死亡率也没有下降。揭示了大量不同部位的局部晚期和被忽视的癌症病例。这些形式的治疗需要多重化疗(PCT)。本研究纳入52例头颈部、胃、大肠等不同部位肿瘤病理患者，分别按照PF、TPF和FOLFOX方案进行辅助化疗，其中5-氟尿嘧啶输注2-5天。本研究根据CTCAE, version 4.03, 2010分析胃肠道毒性。结果显示，与对照组相比，在膳食中添加益生菌Biovestin可使胃肠道毒性降低2倍，并使因副作用发生而中断PCT疗程的风险降低19%。由此可见，添加益生菌Biovestin在PCT条件下预防癌症患者胃肠道疾病方面具有有效性、安全性和使用简便性。
POSSIBILITIES OF NUTRITIONAL SUPPORT WITH PROBIOTIC «BIOVESTIN» IN THE FIGHT WITH GASTROINTESTINAL COMPLICATIONS IN CANCER PATIENTS DURING CHEMOTHERAPY
The incidence of oncological pathology in Russia and throughout the world is steadily growing, and the mortality rate is not decreasing either. A large number of locally advanced and neglected cases of cancer of various location are revealed. Treatment of these forms requires polychemotherapy (PCT). The study included 52 patients with oncological pathology of various location: head and neck, stomach, large intestine, they underwent adjuvant chemotherapy according to the PF, TPF and FOLFOX regimens, which include an infusion of 5-fluorouracil for 2–5 days. The study analyzed gastrointestinal toxicity according to CTCAE, version 4.03, 2010. It was revealed that the addition of the probiotic Biovestin to meal reduces gastrointestinal toxicity by 2 times compared with the control group and reduces the risk of interruption of the PCT course by 19 % due to the development of side effects. Thus, the addition of the probiotic Biovestin has shown its effectiveness, safety and simplicity of use in the prevention of gastrointestinal disorders in cancer patients under conditions of PCT.
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