利用细菌衍生成分进行癌症免疫治疗

Chengxiao Zhang, Y. Mu, Ye Zhuo, Taihua Li, F. Jin, Chun-Zhin Jin, Hyung-Gwan Lee, Long Jin
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引用次数: 1

摘要

近几十年来,细菌相关的癌症免疫治疗由于其机制和在诱导抗肿瘤免疫方面的有用应用而受到了广泛的关注。细菌可以靶向肿瘤,并且可以在肿瘤核心区域定殖。因为它们含有许多与病原体相关的分子模式,即使在抑制抗肿瘤免疫的微环境中,细菌也能有效地刺激免疫细胞,从而增强免疫识别,从而破坏恶性细胞。这篇社论重点介绍了具有免疫治疗作用的各种细菌及其用作免疫治疗药物的副产品。
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Utilizing Bacteria-Derived Components for Cancer Immunotherapy
Bacteria-related cancer immunotherapy, because of its mechanisms and useful applications in the induction of anti-tumor immunity, has gained substantial attention in recent decades. Bacteria can enable targeting of tumors, and specifically can colonize the core tumor area. Because they contain many pathogen-associated molecular patterns—which efficiently stimulate immune cells, even within microenvironments that suppress anti-tumor immunity—bacteria boost immunological recognition leading to the destruction of malignant cells. This Editorial highlights various bacteria with immunotherapeutic effects and their by-products used as immunotherapeutics.
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