纠正实验性糖尿病代谢紊乱的新途径

2018 Ural Symposium on Biomedical Engineering, Radioelectronics and Information Technology (USBEREIT) Pub Date : 2018-05-01 DOI:10.1109/USBEREIT.2018.8384563

V. Emelianov, I. Danilova, I. Gette, K. Sokolova, L. Sidorova, T. Tseitler

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摘要

本研究首次证实了由一系列取代1,3,4-噻二嗪合成的有机化合物L-14与内源性抗坏血酸对四氧嘧啶型糖尿病大鼠的协同作用。表现在减少早期蛋白糖基化产物果糖胺的积累，影响自由基过程和抗氧化保护。

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New approaches to the correction of metabolic disorders in experimental diabetes mellitus

In the study the synergism of synthetic organic compound L-14 from a series of substituted 1,3,4-thiadiazines and an endogenous antioxidant ascorbic acid in alloxan diabetes mellitus in rats was established for the first time. It was manifested in the reduction of accumulation of early protein glycation product — fructosamine, effect on free-radical processes and antioxidant protection.

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2018 Ural Symposium on Biomedical Engineering, Radioelectronics and Information Technology (USBEREIT)

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