帕金森病患者震颤量化及其测量

K. Harish, M. Rao, R. Borgohain, A. Sairam, P. Abhilash
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引用次数: 14

摘要

震颤是身体各部位有节奏的不自主振荡运动,频率和幅度相对固定。它可以在健康受试者以及各种疾病患者中观察到。震颤是神经系统疾病最重要的症状之一。在病理病例中,原发性震颤和帕金森性震颤是最常见的类型。然而,对其进行客观评价是非常困难的。用于量化的方法需要应用诸如低G加速度计和压电探测器之类的设备。本文设计了一种由内置a /D转换的加速度传感器和SPI总线组成的简易测量单元,并将其与单片机连接。微控制器采集三个轴的震动信号。单片机将信号传输到PC机,PC机通过相应的程序获取信号,用MATLAB程序对信号进行处理,测量和量化震颤频率和幅度。通过MATLAB编程建立一套处理规则后,即可设计出可移植的独立系统。所提出的震颤信号采集和处理系统可用于某些神经系统疾病的医学诊断和预后。
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Tremor quantification and its measurements on parkinsonian patients
Tremor is a rhythmic involuntary oscillatory movement of body parts, with a relatively fixed frequency and amplitude. It can be observed in healthy subjects as well as in patients with various diseases. Tremor constitutes one of the most important symptoms of neurological disorders. Among the pathological cases, essential and parkinsonian tremor are the most often observed types. However, its objective assessment is very difficult. The methods used for quantification require application of such devices as low G accelerometers and piezoelectric detectors. In the present paper a simple measuring unit consisting of accelerometer transducer with built in A/D conversion and SPI bus is interfaced to a micro controller. The micro -controller acquires the tremor signal in all the three axes. The micro controller then transmits the signal to a PC, where the suitable program acquires the signal, which can be processed using MATLAB program for measuring and quantifying the tremor frequency and amplitude. After establishing the set of processing rules through MATLAB programming a portable and stand alone system can be designed. The proposed system for acquisition and processing of tremor signals can be used as an aid in both medical diagnosing and prognosis of certain neurological disorders.
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