药物重新分析/重新利用的系统综述

B. Sharma, Dinesh Yadav
{"title":"药物重新分析/重新利用的系统综述","authors":"B. Sharma, Dinesh Yadav","doi":"10.51611/iars.irj.v12i02.2022.218","DOIUrl":null,"url":null,"abstract":"Hardcore capability of drug repurposing has allowed rising population of diversified diseased patients to approach various medications with known safety profiles. In an ongoing scenario considering current pharmaceutical market, we have numerous drugs that are approved and repurposed by the U.S. Food and Drug Administration. Developing and bringing a novel drug molecule from the laboratory to a market requires a lot of investment in terms of money, efforts, and time. On the other hand, repurposing a drug holds the capability of bringing out best cures with harmless, ease availability and inexpensive quality. Sildenafil, Chloroquine, Metformin are some examples of repurposed drug used in multiple disease models. Despite numerous challenges, drug repurposing stood to be a core component to any comprehensive drug re-discovering strategies which has been planned to bring benefit to the patients suffering from a wide variety of dreadful ailments. In this review, we have discussed the various repurposed drugs in numerous types of cancer, deadly novel coronavirus (SARS-CoV-2) and some orphan diseases. This paper holds various examples of drugs which are still under clinical trial and have high chances of being approved as repurposed drugs benefitting humankind.","PeriodicalId":142446,"journal":{"name":"IARS' International Research Journal","volume":"22 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A systematic review on Drug Re-profiling/Re-Purposing\",\"authors\":\"B. Sharma, Dinesh Yadav\",\"doi\":\"10.51611/iars.irj.v12i02.2022.218\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Hardcore capability of drug repurposing has allowed rising population of diversified diseased patients to approach various medications with known safety profiles. In an ongoing scenario considering current pharmaceutical market, we have numerous drugs that are approved and repurposed by the U.S. Food and Drug Administration. Developing and bringing a novel drug molecule from the laboratory to a market requires a lot of investment in terms of money, efforts, and time. On the other hand, repurposing a drug holds the capability of bringing out best cures with harmless, ease availability and inexpensive quality. Sildenafil, Chloroquine, Metformin are some examples of repurposed drug used in multiple disease models. Despite numerous challenges, drug repurposing stood to be a core component to any comprehensive drug re-discovering strategies which has been planned to bring benefit to the patients suffering from a wide variety of dreadful ailments. In this review, we have discussed the various repurposed drugs in numerous types of cancer, deadly novel coronavirus (SARS-CoV-2) and some orphan diseases. This paper holds various examples of drugs which are still under clinical trial and have high chances of being approved as repurposed drugs benefitting humankind.\",\"PeriodicalId\":142446,\"journal\":{\"name\":\"IARS' International Research Journal\",\"volume\":\"22 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-05-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IARS' International Research Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.51611/iars.irj.v12i02.2022.218\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IARS' International Research Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.51611/iars.irj.v12i02.2022.218","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

药物再利用的核心能力使越来越多的不同疾病患者能够使用已知安全性的各种药物。考虑到当前的制药市场,我们有许多药物被美国食品和药物管理局批准和重新利用。开发一种新的药物分子并将其从实验室推向市场需要大量的资金、精力和时间投资。另一方面,重新利用一种药物有能力以无害、容易获得和廉价的质量带来最好的治疗方法。西地那非、氯喹、二甲双胍是在多种疾病模型中使用的重新用途药物的一些例子。尽管面临许多挑战,药物再利用仍然是任何综合性药物再发现战略的核心组成部分,这些战略已计划为患有各种可怕疾病的患者带来好处。在这篇综述中,我们讨论了多种类型的癌症,致命的新型冠状病毒(SARS-CoV-2)和一些孤儿疾病的各种重新用途药物。本文列举了一些仍处于临床试验阶段的药物,这些药物很有可能被批准为造福人类的再用途药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
A systematic review on Drug Re-profiling/Re-Purposing
Hardcore capability of drug repurposing has allowed rising population of diversified diseased patients to approach various medications with known safety profiles. In an ongoing scenario considering current pharmaceutical market, we have numerous drugs that are approved and repurposed by the U.S. Food and Drug Administration. Developing and bringing a novel drug molecule from the laboratory to a market requires a lot of investment in terms of money, efforts, and time. On the other hand, repurposing a drug holds the capability of bringing out best cures with harmless, ease availability and inexpensive quality. Sildenafil, Chloroquine, Metformin are some examples of repurposed drug used in multiple disease models. Despite numerous challenges, drug repurposing stood to be a core component to any comprehensive drug re-discovering strategies which has been planned to bring benefit to the patients suffering from a wide variety of dreadful ailments. In this review, we have discussed the various repurposed drugs in numerous types of cancer, deadly novel coronavirus (SARS-CoV-2) and some orphan diseases. This paper holds various examples of drugs which are still under clinical trial and have high chances of being approved as repurposed drugs benefitting humankind.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Study of Metabolic Syndrome in Pre and Post Menopausal Women Agricultural Waste Management by Hydrothermal Carbonization A Study on Biologically Active Chalcone Based Benzodiazepines A systematic review on Drug Re-profiling/Re-Purposing SYNTHESIS OF α- HYDROXY-β, γ-UNSATURATED ESTERS
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1