{"title":"等离子体增强低语通道模式生物传感","authors":"F. Vollmer","doi":"10.1109/PGC.2012.6458007","DOIUrl":null,"url":null,"abstract":"Whispering gallery mode (WGM) biosensors derive their unprecedented sensitivity for label-free detection of biomolecules from the high-quality (Q) factor of an optical resonance phenomenon. Plasmonic excitations in metal nanostructures which are able to localize the WGM field at the target binding site can further enhance sensitivity by local electric field amplification. Random nanoparticle layers and nanopost antennas are investigated for this purpose, and an efficiency parameter is introduced to quantitate the local field overlap with analyte molecules, a pre-requisite for single molecule detection.","PeriodicalId":158783,"journal":{"name":"2012 Photonics Global Conference (PGC)","volume":"88 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Plasmon-enhanced whispering gallery mode biosensing\",\"authors\":\"F. Vollmer\",\"doi\":\"10.1109/PGC.2012.6458007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Whispering gallery mode (WGM) biosensors derive their unprecedented sensitivity for label-free detection of biomolecules from the high-quality (Q) factor of an optical resonance phenomenon. Plasmonic excitations in metal nanostructures which are able to localize the WGM field at the target binding site can further enhance sensitivity by local electric field amplification. Random nanoparticle layers and nanopost antennas are investigated for this purpose, and an efficiency parameter is introduced to quantitate the local field overlap with analyte molecules, a pre-requisite for single molecule detection.\",\"PeriodicalId\":158783,\"journal\":{\"name\":\"2012 Photonics Global Conference (PGC)\",\"volume\":\"88 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2012 Photonics Global Conference (PGC)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/PGC.2012.6458007\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2012 Photonics Global Conference (PGC)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/PGC.2012.6458007","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Whispering gallery mode (WGM) biosensors derive their unprecedented sensitivity for label-free detection of biomolecules from the high-quality (Q) factor of an optical resonance phenomenon. Plasmonic excitations in metal nanostructures which are able to localize the WGM field at the target binding site can further enhance sensitivity by local electric field amplification. Random nanoparticle layers and nanopost antennas are investigated for this purpose, and an efficiency parameter is introduced to quantitate the local field overlap with analyte molecules, a pre-requisite for single molecule detection.
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