流体动力微镊子的轨道特性研究:含活性粒子的模拟性能

Senanur Düzenli, Jiyan Sürer, A. Tabak
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引用次数: 0

摘要

在微机器人技术中,微操作可以通过不同的策略来捕获、选择和操纵微粒,特别是在生物医学应用中。研究中最常遇到的问题之一是微观物体可能引起的变形或损伤。文献中提出的非接触微操作方法旨在提出有效的解决方案来限制变形效应。这些方法可以根据系统中使用的技术进行分类。利用水动力是文献中最有前途的技术之一。然而,这些系统的数值分析和动态性能预测往往被忽略。本研究尝试了一种基于机器人建模的综合数学模型来研究水动力微镊子系统的水动力相互作用和轨道特性的性能仿真的新方法。此外,我们展示了微镊子系统对特定活性粒子(即大肠杆菌微型细胞)的性能。该系统由一个浸泡在水环境中的磁性球形粒子组成,在外部磁场的作用下旋转,产生自由涡流。作为回报,旋涡被用来捕获上述活性粒子。
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Orbital Characterization Study for the Hydrodynamic Micro Tweezers: Simulated Performance with an Active Particle
In micro-robotics, micromanipulation can be utilized via diverse strategies for the trapping, selection, and manipulation of microparticles especially in biomedical applications. One of the most encountered problems in the research studies is the deformation or damage that might be caused by the micro object. The non-contact micromanipulation methods that are proposed in the literature aim to suggest efficient solutions to limit the deforming effects. These methods can be categorized based on the technique used in the system. The utilization of hydrodynamic forces is one of the most promising techniques in the literature. However, the numerical analysis and the dynamic performance predictions of these systems are often omitted. This study tries a new approach with a robotic-modeling-based comprehensive mathematical model to hydrodynamic interaction and the performance simulation of the orbital characterization of a hydrodynamic micro-tweezers system. Furthermore, we demonstrate the performance of a micro tweezers system on a particular active particle, i.e., E. Coli minicell. The system consists of a magnetic spherical particle submerged in an aqueous environment, rotating by the effects of the external magnetic field resulting in a free vortex. In return, the vortex is employed to trap the said active particle.
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