基于计算平面光学的单镜头、各向同性和小型化微分干涉对比显微镜(SIM-DIC)

Guangwei Hu
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摘要

差干涉对比显微镜(DIC)是透明生物标本成像的一项重要技术。传统系统在4f成像模式下体积庞大,只能进行一维的边缘检测,导致成像的各向异性。在这里,我将介绍我们最近开发的单镜头,各向同性的DIC显微镜在2f系统。这是通过偏振复用超构透镜实现的,它可以在所有方向上进行边缘检测的光学差分计算。我们的工作为医疗保健、环境监测和其他应用的小型化甚至便携式成像系统提供了重要的小型化和小型化显微镜。
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Single-Shot, Isotropic and Miniaturized Differential Interference Contrast (SIM-DIC) Microscopy Based on Computational Flat-Optics
Differential interference contrast (DIC) microscopy is an important technique to imaging the transparent biosamples. Traditional system is bulky in 4f imaging mode, and can only perform edge detection in one dimensional, leading to anisotropic imaging. Here, I will introduce our recently developed single-shot, isotropic DIC microscopy in 2f system. This is realized by a polarization-multiplexed metalens, that can perform the computations of optical difference for edge detections in all directions. Our work promises the important compact and miniaturized microscopy for miniaturized and even portable imaging system for healthcare, environmental monitoring, and other applications.
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