植物提取物改善胃肠道菌群在胃、十二指肠疾病治疗中的作用

O. I. Ergashov
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摘要

本文介绍了一种复合植物提取物组合在应激和乙酰水杨酸胃溃疡实验模型上抗溃疡活性的研究结果,当每一种植物提取物以150 mg/ kg的剂量给药给实验动物。实验对象为非线性雄性大鼠和杂种雄性小鼠。测定Pauls指数、抗溃疡作用指数(AUE)是评价药物抗溃疡活性的主要标准。结果表明,在应激性溃疡中,提取物的有效性表现为减少大、点、条纹状溃疡,减少小鼠溃疡病变数量,AUE指数= 4.6。结果发现,在引入该提取物背景下的乙酰水杨酸胃溃疡模型中,仅70%的动物出现溃疡,对胃粘膜的损伤不明显,AUE指数为4.5。
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The Importance of Plant Extract in Improving the Microflora of the Gastrointestinal Tract in the Treatment of Diseases of the Stomach and Duodenum
The paper presents the results of studying the anti-ulcer activity of a combination of complex plant extracts on experimental models of stress and acetylsalicylic gastric ulcers when administered per os extract at a dose of 150 mg/ kg to laboratory animals. The experiments were performed on nonlinear male rats and mongrel male mice. Determination of the Pauls index, the anti–ulcer action index (AUE) - the main criteria for evaluating the anti-ulcer activity of drugs. It is shown that in stress ulcers, the effectiveness of the extract is characterized by a decrease in large, point, stripe-shaped ulcers, a decrease in the number of ulcerative lesions in mice, the AUE index = 4.6. It was found that in the acetylsalicylic model of gastric ulcers against the background of the introduction of the extract, ulcers were detected only in 70% of animals, less pronounced damage to the gastric mucosa was observed, the AUE index is 4.5.
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