Cancer Detection in Mass Spectrometry Imaging Data by Recurrent Neural Networks

Mass spectrometry imaging (MSI) reveals the localization of a broad scale of compounds ranging from metabolites to proteins in biological tissues. This makes MSI an attractive tool in biomedical research for studying diseases. Computer-aided diagnosis (CAD) systems facilitate the analysis of the molecular profile in tumor tissues to provide a distinctive fingerprint for finding biomarkers. In this paper, the performance of recurrent neural networks (RNNs) is studied on MSI data to exploit their learning capabilities for finding irregular patterns and dependencies in sequential data. In order to design a better CAD model for tumor detection/classification, several configurations of Long Short-Time Memory (LSTM) are examined. The proposed model consists of a 2-layer bidirectional LSTM, each containing 100 LSTM units. The proposed RNN model outperforms the state-of-the-art CNN model by 1.87% and 1.45% higher accuracy in mass spectra classification on lung and bladder cancer datasets with a sixfold faster training time.