{"title":"窄带成像:早期识别口腔扁平苔藓恶性转化的有效工具。一项初步研究","authors":"Parodi A","doi":"10.26420/AUSTINJDERMATOLOG.1087.2019","DOIUrl":null,"url":null,"abstract":"Background: Oral Lichen Planus (OLP) lesions have an overall malignant transformation rate of 1.37%. The diagnosis of malignancy is made by means of a histopathological examination, executed on the basis of a clinical suspicion. Narrow Band Imaging (NBI), a promising endoscopic technique, uses a filtered light with specific wavelengths to highlight microvascular abnormalities associated with subclinical neoplastic changes of the upper aerodigestive tract epithelium. Objective: The study aims to analyze the value of NBI in selecting which patients need to undergo a biopsy before the emergence of clinical changes, allowing early detection of oral malignancies arising from OLP. Methods: A prospective study was conducted enrolling thirty-two consecutive patients with a histological diagnosis of OLP, no previous diagnosis of oral cancer, no other oral inflammatory diseases. Patients with suspicious NBI lesions underwent biopsies; other patients were included in follow-up. Results: Two patients were judged positive at NBI-evaluation; they were both histologically diagnosed of neoplastic lesions. None of the other patients developed clinical features of malignancies during follow-up. Limitations: Patients with negative NBI-evaluation did not undergo biopsies. Conclusion: NBI evaluation could both increase the accuracy of detecting subclinical neoplastic transformation in OLP lesions and help clinicians perform biopsies only in selected cases.","PeriodicalId":247251,"journal":{"name":"Austin Journal of Dermatology","volume":"353 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Narrow-Band Imaging: A Useful Tool to Early Recognize Oral Lichen Planus Malignant Transformation. A Pilot Study\",\"authors\":\"Parodi A\",\"doi\":\"10.26420/AUSTINJDERMATOLOG.1087.2019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Oral Lichen Planus (OLP) lesions have an overall malignant transformation rate of 1.37%. The diagnosis of malignancy is made by means of a histopathological examination, executed on the basis of a clinical suspicion. Narrow Band Imaging (NBI), a promising endoscopic technique, uses a filtered light with specific wavelengths to highlight microvascular abnormalities associated with subclinical neoplastic changes of the upper aerodigestive tract epithelium. Objective: The study aims to analyze the value of NBI in selecting which patients need to undergo a biopsy before the emergence of clinical changes, allowing early detection of oral malignancies arising from OLP. Methods: A prospective study was conducted enrolling thirty-two consecutive patients with a histological diagnosis of OLP, no previous diagnosis of oral cancer, no other oral inflammatory diseases. Patients with suspicious NBI lesions underwent biopsies; other patients were included in follow-up. Results: Two patients were judged positive at NBI-evaluation; they were both histologically diagnosed of neoplastic lesions. None of the other patients developed clinical features of malignancies during follow-up. Limitations: Patients with negative NBI-evaluation did not undergo biopsies. Conclusion: NBI evaluation could both increase the accuracy of detecting subclinical neoplastic transformation in OLP lesions and help clinicians perform biopsies only in selected cases.\",\"PeriodicalId\":247251,\"journal\":{\"name\":\"Austin Journal of Dermatology\",\"volume\":\"353 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-02-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Austin Journal of Dermatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26420/AUSTINJDERMATOLOG.1087.2019\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Austin Journal of Dermatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26420/AUSTINJDERMATOLOG.1087.2019","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Narrow-Band Imaging: A Useful Tool to Early Recognize Oral Lichen Planus Malignant Transformation. A Pilot Study
Background: Oral Lichen Planus (OLP) lesions have an overall malignant transformation rate of 1.37%. The diagnosis of malignancy is made by means of a histopathological examination, executed on the basis of a clinical suspicion. Narrow Band Imaging (NBI), a promising endoscopic technique, uses a filtered light with specific wavelengths to highlight microvascular abnormalities associated with subclinical neoplastic changes of the upper aerodigestive tract epithelium. Objective: The study aims to analyze the value of NBI in selecting which patients need to undergo a biopsy before the emergence of clinical changes, allowing early detection of oral malignancies arising from OLP. Methods: A prospective study was conducted enrolling thirty-two consecutive patients with a histological diagnosis of OLP, no previous diagnosis of oral cancer, no other oral inflammatory diseases. Patients with suspicious NBI lesions underwent biopsies; other patients were included in follow-up. Results: Two patients were judged positive at NBI-evaluation; they were both histologically diagnosed of neoplastic lesions. None of the other patients developed clinical features of malignancies during follow-up. Limitations: Patients with negative NBI-evaluation did not undergo biopsies. Conclusion: NBI evaluation could both increase the accuracy of detecting subclinical neoplastic transformation in OLP lesions and help clinicians perform biopsies only in selected cases.