Pub Date : 2022-07-13DOI: 10.26420/austinjdermatolog.2022.1102
F. R.
Blueberry muffin baby, describes a neonate with multiple purpuras, associated with several conditions in which extra blood is created in the skin. In this report, a premature baby is introduced who had skin lesions in the form of blueberry muffin at birth, and the related differential diagnosis and the final etiology of this baby will be reviewed.
{"title":"Congenital Infection with Cytomegalovirus Presented as Blueberry Muffin Syndrome in a Preterm Newborn: A Case Report","authors":"F. R.","doi":"10.26420/austinjdermatolog.2022.1102","DOIUrl":"https://doi.org/10.26420/austinjdermatolog.2022.1102","url":null,"abstract":"Blueberry muffin baby, describes a neonate with multiple purpuras, associated with several conditions in which extra blood is created in the skin. In this report, a premature baby is introduced who had skin lesions in the form of blueberry muffin at birth, and the related differential diagnosis and the final etiology of this baby will be reviewed.","PeriodicalId":247251,"journal":{"name":"Austin Journal of Dermatology","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132390790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-22DOI: 10.26420/austinjdermatolog.2022.1101
Yokoyama K, Ikeda T, K. T
Granuloma annulare is a benign granulomatous dermatosis with variable clinical presentation. It is of unknown origin and results in erythematous, brown, or skin-colored annular plaques usually found over boney surfaces on the extremities. The main variants are localized granuloma annulare, subcutaneous granuloma annulare, perforating granuloma annulare, and generalized granuloma annulare. Systemic diseases proposed to have an association with granuloma annulare include diabetes mellitus, dyslipidemia, hypothyroidism, and various malignancies. Cohen [1] coined the term ‘malignancy-associated granuloma annulare’ to describe a form of granuloma annulare that is temporally associated with a malignant process, in which the onset of granuloma annulare coincides with the discovery of a previously unsuspected neoplasm or metastatic disease, and the course of the granuloma annulare also parallels that of the tumor. We present a Japanese patient with malignancy-associated generalized granuloma annulare as the first manifestation of stomach cancer based on diabetes mellitus.
{"title":"Malignancy-Associated Generalized Granuloma Annulare in a Japanese Patient with Stomach Cancer and Diabetes Mellitus","authors":"Yokoyama K, Ikeda T, K. T","doi":"10.26420/austinjdermatolog.2022.1101","DOIUrl":"https://doi.org/10.26420/austinjdermatolog.2022.1101","url":null,"abstract":"Granuloma annulare is a benign granulomatous dermatosis with variable clinical presentation. It is of unknown origin and results in erythematous, brown, or skin-colored annular plaques usually found over boney surfaces on the extremities. The main variants are localized granuloma annulare, subcutaneous granuloma annulare, perforating granuloma annulare, and generalized granuloma annulare. Systemic diseases proposed to have an association with granuloma annulare include diabetes mellitus, dyslipidemia, hypothyroidism, and various malignancies. Cohen [1] coined the term ‘malignancy-associated granuloma annulare’ to describe a form of granuloma annulare that is temporally associated with a malignant process, in which the onset of granuloma annulare coincides with the discovery of a previously unsuspected neoplasm or metastatic disease, and the course of the granuloma annulare also parallels that of the tumor. We present a Japanese patient with malignancy-associated generalized granuloma annulare as the first manifestation of stomach cancer based on diabetes mellitus.","PeriodicalId":247251,"journal":{"name":"Austin Journal of Dermatology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114209703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-05DOI: 10.26420/austinjdermatolog.2022.1100
Shah Ma, Khamdan Fa, Khamdan Ma, Alkhayyat Rmh
Wells syndrome, also known as eosinophilic cellulitis, is an inflammatory dermatitis that is often misdiagnosed as infectious cellulitis, leading to the inappropriate use of antibiotics and a delay appropriate treatment. We present a diagnostically challenging case where a 65-year-old male with a known case of SLL was found to have eosinophilic dermatosis of hematological malignancy after a thorough workup. Although the association between CLL and Wells syndrome is well established, we have not encountered any similar association or other cases of Wells syndrome associated with SLL in the literature. The pathophysiology underlying the association between eosinophilic cellulitis and CLL/SLL remains incompletely understood, and further investigation is warranted.
{"title":"Eosinophilic Dermatosis of Hematological Malignancy Mimicking Wells Syndrome","authors":"Shah Ma, Khamdan Fa, Khamdan Ma, Alkhayyat Rmh","doi":"10.26420/austinjdermatolog.2022.1100","DOIUrl":"https://doi.org/10.26420/austinjdermatolog.2022.1100","url":null,"abstract":"Wells syndrome, also known as eosinophilic cellulitis, is an inflammatory dermatitis that is often misdiagnosed as infectious cellulitis, leading to the inappropriate use of antibiotics and a delay appropriate treatment. We present a diagnostically challenging case where a 65-year-old male with a known case of SLL was found to have eosinophilic dermatosis of hematological malignancy after a thorough workup. Although the association between CLL and Wells syndrome is well established, we have not encountered any similar association or other cases of Wells syndrome associated with SLL in the literature. The pathophysiology underlying the association between eosinophilic cellulitis and CLL/SLL remains incompletely understood, and further investigation is warranted.","PeriodicalId":247251,"journal":{"name":"Austin Journal of Dermatology","volume":"157 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128769747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-26DOI: 10.26420/austinjdermatolog.2021.1099
Guerrero-Putz Md, Gomez-Flores M, Ocampo-Candiani J, Alba-Rojas E
Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are hypersensitivity reaction, mainly to drugs, characterized by skin detachment. They are dermatological emergencies, and bacteremia is the main cause death, especially in patients with extensive cutaneous involvement. We reviewed and summarized the large retrospective studies that focused on the risk factors and main pathogens involved in patients with SJS and TEN who developed bacteremia. Our results showed that the risk factors include a Total Body Surface Area (TBSA) higher than 10%, higher Severity-of-Illness Score For Toxic Epidermal Necrolysis (SCORTEN), hypertension, previous opiate use, White Blood Cells (WBC) > 10000/mL; C-Reactive Protein (CRP) > 100mg/mL; procalcitonin (PCT) ≥ 1μg/L; and skin colonization with P. aeruginosa, S. aureus, and methicillin-resistant S. aureus (MRSA). The most frequently isolated pathogens from blood cultures were S. aureus, E. faecalis, P. aeruginosa, Enterobacter spp, and A. baumannii. The identification and consideration of these variables on each patient with SJS and TEN could result in an earlier diagnosis, proper management and even prevention of bacteremia in this population.
{"title":"Bacteremia in Stevens Johnson Syndrome and Toxic Epidermal Necrolysis: Main Pathogens and Risk Factors: A Mini Review","authors":"Guerrero-Putz Md, Gomez-Flores M, Ocampo-Candiani J, Alba-Rojas E","doi":"10.26420/austinjdermatolog.2021.1099","DOIUrl":"https://doi.org/10.26420/austinjdermatolog.2021.1099","url":null,"abstract":"Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are hypersensitivity reaction, mainly to drugs, characterized by skin detachment. They are dermatological emergencies, and bacteremia is the main cause death, especially in patients with extensive cutaneous involvement. We reviewed and summarized the large retrospective studies that focused on the risk factors and main pathogens involved in patients with SJS and TEN who developed bacteremia. Our results showed that the risk factors include a Total Body Surface Area (TBSA) higher than 10%, higher Severity-of-Illness Score For Toxic Epidermal Necrolysis (SCORTEN), hypertension, previous opiate use, White Blood Cells (WBC) > 10000/mL; C-Reactive Protein (CRP) > 100mg/mL; procalcitonin (PCT) ≥ 1μg/L; and skin colonization with P. aeruginosa, S. aureus, and methicillin-resistant S. aureus (MRSA). The most frequently isolated pathogens from blood cultures were S. aureus, E. faecalis, P. aeruginosa, Enterobacter spp, and A. baumannii. The identification and consideration of these variables on each patient with SJS and TEN could result in an earlier diagnosis, proper management and even prevention of bacteremia in this population.","PeriodicalId":247251,"journal":{"name":"Austin Journal of Dermatology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116809796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-13DOI: 10.26420/austinjdermatolog.2021.1098
Gatzka Mv, C. P., Czech Wj
Psoriasis is a chronic recurrent inflammatory disease of the skin and joints mediated by different subsets of T-cells and other immune cells. Known trigger factors of psoriasis include bacterial, viral and fungal infections, various drugs, stress, and mechanic irritation. Onset of psoriasis post vaccination for influenza, tuberculosis and pneumococcal pneumonia has been observed, but the exact mechanisms are still unclear. We herein report of an elderly patient with a history of mild to moderate psoriasis episodes in the past years experiencing a severe generalized psoriasis flare-up two weeks after the second dose of a COVID-19 mRNA vaccination with Corminaty (bnt162b2 biontech/pfizer) had been administered. In the light of current data on psoriasis onset in context with COVID-19, potential molecular psoriasis trigger factors and disease mechanisms are briefly reviewed.
{"title":"Psoriasis Exacerbation Following COVID-19 Mrna Vaccination in an Elderly Patient","authors":"Gatzka Mv, C. P., Czech Wj","doi":"10.26420/austinjdermatolog.2021.1098","DOIUrl":"https://doi.org/10.26420/austinjdermatolog.2021.1098","url":null,"abstract":"Psoriasis is a chronic recurrent inflammatory disease of the skin and joints mediated by different subsets of T-cells and other immune cells. Known trigger factors of psoriasis include bacterial, viral and fungal infections, various drugs, stress, and mechanic irritation. Onset of psoriasis post vaccination for influenza, tuberculosis and pneumococcal pneumonia has been observed, but the exact mechanisms are still unclear. We herein report of an elderly patient with a history of mild to moderate psoriasis episodes in the past years experiencing a severe generalized psoriasis flare-up two weeks after the second dose of a COVID-19 mRNA vaccination with Corminaty (bnt162b2 biontech/pfizer) had been administered. In the light of current data on psoriasis onset in context with COVID-19, potential molecular psoriasis trigger factors and disease mechanisms are briefly reviewed.","PeriodicalId":247251,"journal":{"name":"Austin Journal of Dermatology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115344023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-22DOI: 10.26420/austinjdermatolog.2021.1096
Bouabdella S, A. S., Zizi N, Dikhaye S
Epidermodysplasia verruciformis is an uncommon disorder that is transmitted in an autosomal recessive manner. It is characterized by increased susceptibility to human papillomavirus infection, which presents with hypo- or hyperpigmented macular lesions, pityriasis versicolor-like lesions, and an early tendency to transform into skin cancer. We present a case of a 40-year-old male with complaints of verrucous lesions of the hands and feet. Histopathology was suggestive of EV.
{"title":"Epidermodysplasia Verruciformis: A Case Report and a Brief Review","authors":"Bouabdella S, A. S., Zizi N, Dikhaye S","doi":"10.26420/austinjdermatolog.2021.1096","DOIUrl":"https://doi.org/10.26420/austinjdermatolog.2021.1096","url":null,"abstract":"Epidermodysplasia verruciformis is an uncommon disorder that is transmitted in an autosomal recessive manner. It is characterized by increased susceptibility to human papillomavirus infection, which presents with hypo- or hyperpigmented macular lesions, pityriasis versicolor-like lesions, and an early tendency to transform into skin cancer. We present a case of a 40-year-old male with complaints of verrucous lesions of the hands and feet. Histopathology was suggestive of EV.","PeriodicalId":247251,"journal":{"name":"Austin Journal of Dermatology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116578233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-22DOI: 10.26420/austinjdermatolog.2021.1097
N. S, M. A, Yousif J, Warbasse E, Potts G
As many as 73% of patients scheduled to undergo surgery have substantial preoperative anxiety [1]. Significant preoperative anxiety has also been reported in fast track and day-care patients [2]. Dermatologists perform a number of procedures ranging from skin biopsies to Mohs micrographic surgery. Patients may experience anxiety prior to such procedures, termed pre-procedural or preoperative anxiety. Patient anxiety prior to dermatologic surgery may be influenced by factors such as the sight of blood, perception of pain during the surgery, and potential complications of surgery. Given the role of preoperative anxiety in affecting tolerance of the procedure, intra- and postoperative complications, and overall satisfaction, further research is warranted to determine how best to reduce preprocedural anxiety in dermatologic procedures.
{"title":"Pre-Procedural Patient Anxiety in Dermatologic Procedures: A Cross-Sectional Study of Dermatologists","authors":"N. S, M. A, Yousif J, Warbasse E, Potts G","doi":"10.26420/austinjdermatolog.2021.1097","DOIUrl":"https://doi.org/10.26420/austinjdermatolog.2021.1097","url":null,"abstract":"As many as 73% of patients scheduled to undergo surgery have substantial preoperative anxiety [1]. Significant preoperative anxiety has also been reported in fast track and day-care patients [2]. Dermatologists perform a number of procedures ranging from skin biopsies to Mohs micrographic surgery. Patients may experience anxiety prior to such procedures, termed pre-procedural or preoperative anxiety. Patient anxiety prior to dermatologic surgery may be influenced by factors such as the sight of blood, perception of pain during the surgery, and potential complications of surgery. Given the role of preoperative anxiety in affecting tolerance of the procedure, intra- and postoperative complications, and overall satisfaction, further research is warranted to determine how best to reduce preprocedural anxiety in dermatologic procedures.","PeriodicalId":247251,"journal":{"name":"Austin Journal of Dermatology","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117176726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.26420/austinjdermatolog.2021.1094
D. M
Introduction Sarcoidosis is a multisystem inflammatory disease defined histologically by the formation of non-caseating granulomas. Cardiac involvement can be seen in up to 5% of cases [1]. These patients are at a high risk for major cardiac events [1]. Diagnosing and monitoring Cardiac Sarcoidosis (CS) is not trivial but can be currently accomplished by a combination of cardiac MRI and cardiac FDG PET-CT scanning [2]. With appropriate patient preparation, cardiac FDG PET has a high sensitivity for detecting cardiac lesions but also extra-cardiac lesions and for monitoring the efficacy of treatment. Discussion Current standard clinical practice consists of acquiring dedicated, limited field of view cardiac FDG PET scans. This would cover the heart and immediately adjacent thoracic structures. Although this is of great value and used with great success to diagnose and monitor cardiac sarcoidosis, it fails to assess the patient’s disease in a holistic manner. Still with this limited field of view, several reports including ours have described a high rate of extra-cardiac findings. We reviewed a series of sixty-five PET-CT scans of 54 patients referred for CS evaluation. These were performed between September 2010 and April 2013 at Yale New Haven Hospital and we found extra-cardiac findings were present in 92.3% of scans (n=60). Overall disease distribution is summarized in (Table 1). Highlight some of these extra-cardiac findings (Figures 1-4). 52.3% of these patients were asymptomatic at the time of the scan. CS was diagnosed in 50.8% of patients (n=33). All the patients (100%) with CS had extra-cardiac findings. Additionally, extra-cardiac findings were present in 48.3% of the scans when there was no cardiac involvement. In our cohort, we had no cases of Isolated Cardiac Sarcoidosis (ICS).
{"title":"Whole Body FDG PET-CT in the Evaluation and Management of Cardiac Sarcoidosis and Isolated Cardiac Sarcoidosis","authors":"D. M","doi":"10.26420/austinjdermatolog.2021.1094","DOIUrl":"https://doi.org/10.26420/austinjdermatolog.2021.1094","url":null,"abstract":"Introduction Sarcoidosis is a multisystem inflammatory disease defined histologically by the formation of non-caseating granulomas. Cardiac involvement can be seen in up to 5% of cases [1]. These patients are at a high risk for major cardiac events [1]. Diagnosing and monitoring Cardiac Sarcoidosis (CS) is not trivial but can be currently accomplished by a combination of cardiac MRI and cardiac FDG PET-CT scanning [2]. With appropriate patient preparation, cardiac FDG PET has a high sensitivity for detecting cardiac lesions but also extra-cardiac lesions and for monitoring the efficacy of treatment. Discussion Current standard clinical practice consists of acquiring dedicated, limited field of view cardiac FDG PET scans. This would cover the heart and immediately adjacent thoracic structures. Although this is of great value and used with great success to diagnose and monitor cardiac sarcoidosis, it fails to assess the patient’s disease in a holistic manner. Still with this limited field of view, several reports including ours have described a high rate of extra-cardiac findings. We reviewed a series of sixty-five PET-CT scans of 54 patients referred for CS evaluation. These were performed between September 2010 and April 2013 at Yale New Haven Hospital and we found extra-cardiac findings were present in 92.3% of scans (n=60). Overall disease distribution is summarized in (Table 1). Highlight some of these extra-cardiac findings (Figures 1-4). 52.3% of these patients were asymptomatic at the time of the scan. CS was diagnosed in 50.8% of patients (n=33). All the patients (100%) with CS had extra-cardiac findings. Additionally, extra-cardiac findings were present in 48.3% of the scans when there was no cardiac involvement. In our cohort, we had no cases of Isolated Cardiac Sarcoidosis (ICS).","PeriodicalId":247251,"journal":{"name":"Austin Journal of Dermatology","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115743677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-25DOI: 10.26420/austinjdermatolog.2021.1095
D. M
Hemophagocytic Lymphohistiocytosis (HLH) is a rare disorder. It progresses rapidly and can be life-threatening. Prompt initiation of treatment is critical for survival. Untreated, patients survive only a few months. These patients have multisystem involvement and may develop multi-organ failure. The goal of therapy for patients with HLH is to suppress life-threatening inflammation. After induction, patients who are recovering are weaned off therapy, while those who are not improving are continued on therapy as a potential bridge to stem cell transplantation. Monitoring treatment response is critical as treatment escalation may be warranted if the patient is not improving. The distinction between chemotherapy toxicity and worsening disease may be difficult to make clinically. Quite a variety of clinical, biochemical and immunological biomarkers are used at diagnosis and to assess treatment response. The response to initial therapy is a major factor in determining the need for additional therapy including Hematopoietic Cell Transplant (HCT). Response to induction therapy is monitored by assessing the patient clinically and using HLH disease-specific markers. Although this approach has some success, it is sometimes confounded by a new infection or treatment toxicity. Imaging can provide an additional layer of accuracy in the initial evaluation of HLH patients as well as their monitoring and follow-up. 18F-FDG PET scans are highly sensitive and can be quite helpful in the management of these patients (Figure 1).
{"title":"FDG PET Scanning in Hemophagocytic Lymphohistiocytosis","authors":"D. M","doi":"10.26420/austinjdermatolog.2021.1095","DOIUrl":"https://doi.org/10.26420/austinjdermatolog.2021.1095","url":null,"abstract":"Hemophagocytic Lymphohistiocytosis (HLH) is a rare disorder. It progresses rapidly and can be life-threatening. Prompt initiation of treatment is critical for survival. Untreated, patients survive only a few months. These patients have multisystem involvement and may develop multi-organ failure. The goal of therapy for patients with HLH is to suppress life-threatening inflammation. After induction, patients who are recovering are weaned off therapy, while those who are not improving are continued on therapy as a potential bridge to stem cell transplantation. Monitoring treatment response is critical as treatment escalation may be warranted if the patient is not improving. The distinction between chemotherapy toxicity and worsening disease may be difficult to make clinically. Quite a variety of clinical, biochemical and immunological biomarkers are used at diagnosis and to assess treatment response. The response to initial therapy is a major factor in determining the need for additional therapy including Hematopoietic Cell Transplant (HCT). Response to induction therapy is monitored by assessing the patient clinically and using HLH disease-specific markers. Although this approach has some success, it is sometimes confounded by a new infection or treatment toxicity. Imaging can provide an additional layer of accuracy in the initial evaluation of HLH patients as well as their monitoring and follow-up. 18F-FDG PET scans are highly sensitive and can be quite helpful in the management of these patients (Figure 1).","PeriodicalId":247251,"journal":{"name":"Austin Journal of Dermatology","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127289576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-14DOI: 10.26420/austinjdermatolog.2021.1093
Ibrahim ElGhareeb M, E. S, Fathi M, K. N, Gado M
Background: Vitiligo is an acquired depigmented disorder characterized by milky-white macules in the skin. Interleukin-17 has important role in autoimmune diseases development like vitiligo. Interleukin-33 is released after tissue damage or cell death. It may reflect recent disease activity. Aim: To measure serum levels of IL17 and IL-33 in vitiligo patients and to assess their relationship with disease activity. Methods: Levels of IL17 and IL-33 in serum samples taken from 21 healthy normal subjects and 21 vitiligo patients were measured by ELISA. All the patients were subjected to careful history taking , general examination and local examination to assess extent ,activity of vitiligo and VASI score. Results: IL17 and IL-33 serum levels were highly statistically significant increase in patients with vitiligo than the normal control subjects(p≤0.001). Their levels were related to disease activity and the extent of the disease. Interleukin 17 serum levels were positively correlated with IL-33 serum levels. Conclusion: Increased serum levels of IL-17 and IL-33 in vitiligo patients and their levels were related to disease activity and the extent of the disease indicating that IL-17 and IL-33 may play a role in the pathogenesis of vitiligo.
{"title":"Serum Interleukin 17 and Interleukin 33 in Vitiligo Egyptian Patients","authors":"Ibrahim ElGhareeb M, E. S, Fathi M, K. N, Gado M","doi":"10.26420/austinjdermatolog.2021.1093","DOIUrl":"https://doi.org/10.26420/austinjdermatolog.2021.1093","url":null,"abstract":"Background: Vitiligo is an acquired depigmented disorder characterized by milky-white macules in the skin. Interleukin-17 has important role in autoimmune diseases development like vitiligo. Interleukin-33 is released after tissue damage or cell death. It may reflect recent disease activity. Aim: To measure serum levels of IL17 and IL-33 in vitiligo patients and to assess their relationship with disease activity. Methods: Levels of IL17 and IL-33 in serum samples taken from 21 healthy normal subjects and 21 vitiligo patients were measured by ELISA. All the patients were subjected to careful history taking , general examination and local examination to assess extent ,activity of vitiligo and VASI score. Results: IL17 and IL-33 serum levels were highly statistically significant increase in patients with vitiligo than the normal control subjects(p≤0.001). Their levels were related to disease activity and the extent of the disease. Interleukin 17 serum levels were positively correlated with IL-33 serum levels. Conclusion: Increased serum levels of IL-17 and IL-33 in vitiligo patients and their levels were related to disease activity and the extent of the disease indicating that IL-17 and IL-33 may play a role in the pathogenesis of vitiligo.","PeriodicalId":247251,"journal":{"name":"Austin Journal of Dermatology","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121930788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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