葡萄糖对马来无并发症2型糖尿病患者还原性谷胱甘肽水平的影响

Subandrate, Raafqi Ranasasmita
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摘要

背景:血糖水平升高可能增加2型糖尿病患者的自由基化合物。自由基化合物可引起氧化应激,从而减少内源性抗氧化剂,如还原性谷胱甘肽(GSH)。目的:本研究旨在确定随机血糖水平是否影响马来族2型糖尿病患者的谷胱甘肽。方法:本研究采用病例对照观察法,纳入25例无并发症的2型糖尿病患者(接受二甲双胍和/或格米吡脲治疗)和25例健康对照。使用ACCU-CHECK®试剂盒随机测定血糖水平。采用Sigma谷胱甘肽测定试剂盒测定血谷胱甘肽水平。结果:2型糖尿病患者的随机血糖水平明显低于年龄匹配的正常人(p<0.0001)。2型糖尿病患者GSH水平明显低于同龄正常受试者(p=0.00)。我们发现随机血糖水平与GSH水平呈中度负相关(r=-0.437, p=0.02)。结论:高血糖时GSH的消耗可中和葡萄糖丰富间接产生的自由基。
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Effect of glucose on reduced glutathione level in Malay uncomplicated type 2 diabetes patients
Background: Increasing blood sugar level may increase free radical compounds in type 2 diabetes. Free radical compounds can cause oxidative stress, thereby decreasing endogenous antioxidants such as reduced glutathione (GSH). Objective: This study aimed to determine whether random blood glucose levels affect GSH in type 2 diabetes patients within the Malay race. Methods: This study was observational with case-control, involving 25 patients with uncomplicated type 2 diabetes (receiving metformin and/or glimipiride) and 25 healthy controls. Random blood glucose levels were determined using ACCU-CHECK® Kit. Blood GSH levels were determined by Sigma GSH Assay Kit. Results: Results show that type 2 diabetes patients have a significantly lower random blood glucose level compared with those of age-matched normal subjects (p<0.0001). Type 2 diabetic patients had significantly lower levels of GSH (p=0.00) than those of age-matched normal subjects. We found a moderate negative correlation (r=-0.437 and p=0.02) between the level of random blood glucose and the level of GSH. Conclusion: The depletion of GSH during hyperglycemia may neutralize the free radicals indirectly generated by the abundant of glucose.  
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