基于模型的心血管系统自主调节评价方法

Lang Wang, Zhipei Huang, Jiankang Wu, Yu Meng, R. Ding
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引用次数: 4

摘要

心血管系统自主调节的定量测量在多种心血管疾病中具有临床和预后价值。本文提出了一种基于模型的测量压力反射敏感性、交感神经和副交感神经活动的方法。该方法测量直立状态下的连续血压和心率,模拟压力反射和交感调节过程,并利用测量的血压和心率变化优化求解个性化模型参数。实验结果表明了定量措施的有效性和方法的有效性。
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A model-based method to evaluate autonomic regulation of cardiovascular system
Quantitative measures of autonomic regulation of cardiovascular system have clinical and prognostic value in a variety of cardiovascular diseases. This paper proposes a model-based method in the measurement of baroreflex sensitivity, sympathetic and parasympathetic activity. The method measures the continuous blood pressure and heart rate in orthostatic scenario, models the baroreflex and sympathetic regulation process, solves for personalized model parameters by optimization using measured blood pressure and heart rate variations. Experimental results have shown the validation of the quantitative measures and the effectiveness of the method.
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