COVID-19 Scratch模型支持本地决策

E. H. Kaplan
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引用次数: 21

摘要

本文基于在SARS-CoV-2爆发的最初几周应耶鲁大学、耶鲁纽黑文医院和康涅狄格州的要求进行的建模研究。大部分工作依赖于scratch建模,也就是说,实时从零开始创建模型。应用程序包括建议事件人群规模限制,医院激增计划,时间决定(何时停止和可能重新开始大学活动),以及情景分析以评估替代干预措施的影响,以及其他问题。本文记录了在地方一级实时应对COVID-19危机过程中面临的问题、开发的模式以及提供的建议。结果包括一个简单的事件最大规模公式,该公式可确保99%的概率没有感染者;确定现有ICU容量不足以应对COVID-19的到来,从而创建了大型专用COVID-19负压ICU;一个新的流行病模型表明,大学举办正常的春季和夏季活动是不可行的,如果没有额外的公共卫生行动,封锁式的居家和社交距离限制只会延迟传播,并在限制解除后使疫情反弹,积极的社区筛查迅速发现和隔离感染者可能会结束疫情。
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COVID-19 Scratch Models To Support Local Decisions
This article is based on modeling studies conducted in response to requests from Yale University, the Yale New Haven Hospital and the State of Connecticut during the early weeks of the SARS-CoV-2 outbreak. Much of this work relied on scratch modeling, that is, models created from scratch in real time. Applications included recommending event crowd-size restrictions, hospital surge planning, timing decisions (when to stop and possibly restart university activities), and scenario analyses to assess the impacts of alternative interventions, among other problems. This paper documents the problems faced, models developed, and advice offered during real-time response to the COVID-19 crisis at the local level. Results include a simple formula for the maximum size of an event that ensures no infected persons are present with 99% probability; the determination that existing ICU capacity was insufficient for COVID-19 arrivals which led to creating a large dedicated COVID-19 negative pressure ICU; and a new epidemic model that showed the infeasibility of the university hosting normal spring and summer events, that lockdown-like stay-at-home and social distancing restrictions without additional public health action would only delay transmission and enable a rebound after restrictions are lifted, and that aggressive community screening to rapidly detect and isolate infected persons could end the outbreak.
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