多位点蛋白亚细胞定位的预测

Qing Zhao, N. Li, Li Fang
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引用次数: 0

摘要

多位点蛋白质亚细胞定位预测与蛋白质功能、代谢和信号转导密切相关。它在推测蛋白质的生物学功能、明确基因功能、阐明疾病的内在机制等方面具有重要作用。由于一些蛋白质同时位于两个或多个亚细胞中,因此有必要进行多位点蛋白质亚细胞定位预测的研究。本文从数据集构建、蛋白质特征提取、预测算法和算法评价四个方面对该问题进行了综述。
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Prediction of Multi-site Protein Subcellular Localization
Multi-site protein subcellular localization prediction has close relationship with protein function, metabolic and transduction between signals. It can play an important role in speculating the biological function of protein, clearing the gene function and clarifying the internal mechanism of diseases. As some proteins located in two or more subcellulars at the same time, it is necessary for us to do the research on multi-site protein subcellular localization prediction. This paper reviewed the problem from the following four aspects, dataset construction, protein features extraction, predicting algorithm and algorithm evaluation.
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