{"title":"引起儿童尿路感染的肠球菌的诊断和耐药性","authors":"Crina Dănăilă, Marius-Ciprian Ungureanu, Lavinia-Emilia Petcu","doi":"10.54044/rami.2022.02.06","DOIUrl":null,"url":null,"abstract":"Introduction: Among Gram-positive bacteria, enterococci are considered the most frequent pathogens in the case of urinary tract infections (UTIs) in children. It is known that enterococci have intrinsic resistance and acquired resistance is achieved by different mechanisms for: beta-lactams, aminoglycosides, quinolones, glycopeptides and linezolid. Objectives: The purpose of this review is to demonstrate that Enterococcus spp. is a frequent cause of urinary infections in children and to analyze antibiotic resistance. Materials and methods: The research was conducted using specific keywords such as “antibiotic resistance”, “children”, “UTI”, “Enterococcus spp.”, and “biofilm”, in specialty books, Google Scholar, PubMed, ScienceDirect and PubMed Central (PMC). Results: Antibiotic resistance of Enterococcus spp. is an issue in the choice of treatment for urinary tract infections. According to certain research, resistance to vancomycin has increased in some countries while decreasing in others. Another concerning problem is the observed gentamicin resistance, notably in Enterococcus faecium. Discussion: Virulence factors, particularly Esp, which is involved in biofilm formation, play a key role in the processes of antibiotic resistance development. The presence of vanA and vanB genes modifies the structure of the bacteria and leads to the emergence of antibiotic resistance. Enterococcal resistance to vancomycin (VRE) represents a major public health problem and is the main mechanism that occurs in nosocomial infections. Conclusions: Enterococcus spp. is one of the most prevalent etiological agents in urinary pathology and a common source of nosocomial infections. Because of the presence of virulence factors and genes, these bacteria can easily acquire resistance to specific antibiotics. Keywords: antibiotic resistance, children, UTI, Enterococcus spp., biofilm","PeriodicalId":237638,"journal":{"name":"Romanian Archives of Microbiology and Immunology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"DIAGNOSIS AND ANTIBIOTIC RESISTANCE OF ENTEROCOCCUS SPP. CAUSING URINARY TRACT INFECTIONS IN CHILDREN\",\"authors\":\"Crina Dănăilă, Marius-Ciprian Ungureanu, Lavinia-Emilia Petcu\",\"doi\":\"10.54044/rami.2022.02.06\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Among Gram-positive bacteria, enterococci are considered the most frequent pathogens in the case of urinary tract infections (UTIs) in children. It is known that enterococci have intrinsic resistance and acquired resistance is achieved by different mechanisms for: beta-lactams, aminoglycosides, quinolones, glycopeptides and linezolid. Objectives: The purpose of this review is to demonstrate that Enterococcus spp. is a frequent cause of urinary infections in children and to analyze antibiotic resistance. Materials and methods: The research was conducted using specific keywords such as “antibiotic resistance”, “children”, “UTI”, “Enterococcus spp.”, and “biofilm”, in specialty books, Google Scholar, PubMed, ScienceDirect and PubMed Central (PMC). Results: Antibiotic resistance of Enterococcus spp. is an issue in the choice of treatment for urinary tract infections. According to certain research, resistance to vancomycin has increased in some countries while decreasing in others. Another concerning problem is the observed gentamicin resistance, notably in Enterococcus faecium. Discussion: Virulence factors, particularly Esp, which is involved in biofilm formation, play a key role in the processes of antibiotic resistance development. The presence of vanA and vanB genes modifies the structure of the bacteria and leads to the emergence of antibiotic resistance. Enterococcal resistance to vancomycin (VRE) represents a major public health problem and is the main mechanism that occurs in nosocomial infections. Conclusions: Enterococcus spp. is one of the most prevalent etiological agents in urinary pathology and a common source of nosocomial infections. Because of the presence of virulence factors and genes, these bacteria can easily acquire resistance to specific antibiotics. Keywords: antibiotic resistance, children, UTI, Enterococcus spp., biofilm\",\"PeriodicalId\":237638,\"journal\":{\"name\":\"Romanian Archives of Microbiology and Immunology\",\"volume\":\"14 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Romanian Archives of Microbiology and Immunology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.54044/rami.2022.02.06\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Romanian Archives of Microbiology and Immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.54044/rami.2022.02.06","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
在革兰氏阳性细菌中,肠球菌被认为是儿童尿路感染(uti)病例中最常见的病原体。众所周知,肠球菌具有内在耐药性,获得性耐药是通过不同的机制实现的:β -内酰胺类、氨基糖苷类、喹诺酮类、糖肽和利奈唑胺。目的:本综述的目的是证明肠球菌是儿童尿路感染的常见原因,并分析抗生素耐药性。材料与方法:研究使用专业图书、谷歌Scholar、PubMed、ScienceDirect和PubMed Central (PMC)中的“抗生素耐药性”、“儿童”、“UTI”、“Enterococcus spp”、“biofilm”等特定关键词进行。结果:肠球菌对抗生素的耐药性是泌尿道感染治疗选择中的一个问题。根据某些研究,对万古霉素的耐药性在一些国家有所增加,而在另一些国家有所下降。另一个值得关注的问题是观察到的庆大霉素耐药性,特别是在粪肠球菌中。讨论:毒力因子,特别是参与生物膜形成的Esp,在抗生素耐药性的发展过程中起着关键作用。vanA和vanB基因的存在改变了细菌的结构,导致抗生素耐药性的出现。肠球菌对万古霉素的耐药性是一个重大的公共卫生问题,也是院内感染发生的主要机制。结论:肠球菌是泌尿系统疾病中最常见的病原之一,也是医院感染的常见来源。由于毒力因子和基因的存在,这些细菌很容易获得对特定抗生素的耐药性。关键词:抗生素耐药性,儿童,尿路感染,肠球菌,生物膜
DIAGNOSIS AND ANTIBIOTIC RESISTANCE OF ENTEROCOCCUS SPP. CAUSING URINARY TRACT INFECTIONS IN CHILDREN
Introduction: Among Gram-positive bacteria, enterococci are considered the most frequent pathogens in the case of urinary tract infections (UTIs) in children. It is known that enterococci have intrinsic resistance and acquired resistance is achieved by different mechanisms for: beta-lactams, aminoglycosides, quinolones, glycopeptides and linezolid. Objectives: The purpose of this review is to demonstrate that Enterococcus spp. is a frequent cause of urinary infections in children and to analyze antibiotic resistance. Materials and methods: The research was conducted using specific keywords such as “antibiotic resistance”, “children”, “UTI”, “Enterococcus spp.”, and “biofilm”, in specialty books, Google Scholar, PubMed, ScienceDirect and PubMed Central (PMC). Results: Antibiotic resistance of Enterococcus spp. is an issue in the choice of treatment for urinary tract infections. According to certain research, resistance to vancomycin has increased in some countries while decreasing in others. Another concerning problem is the observed gentamicin resistance, notably in Enterococcus faecium. Discussion: Virulence factors, particularly Esp, which is involved in biofilm formation, play a key role in the processes of antibiotic resistance development. The presence of vanA and vanB genes modifies the structure of the bacteria and leads to the emergence of antibiotic resistance. Enterococcal resistance to vancomycin (VRE) represents a major public health problem and is the main mechanism that occurs in nosocomial infections. Conclusions: Enterococcus spp. is one of the most prevalent etiological agents in urinary pathology and a common source of nosocomial infections. Because of the presence of virulence factors and genes, these bacteria can easily acquire resistance to specific antibiotics. Keywords: antibiotic resistance, children, UTI, Enterococcus spp., biofilm