Novel circular microchannels fabrication method for artery thrombosis investigation

This paper demonstrates the straightforward fabrication process of polydimethylsiloxane (PDMS) circular cross-section microfluidic channels by using air pressure to define the deformation of partially cured PDMS surface. Based on this technique, circular cross-section microchannel can be easily produced in a wide range of dimensions from 100 μm to 500 μm with simple bench top equipment. Using self-alignment and bonding with partially cured PDMS, this technique can eliminate air plasma activated bonding and tedious alignment processes. We successfully used the technique to fabricate multiple dimensions of circular microchannels to mimic the artery for investigating artery thrombosis phenomenon on a chip.