Christian E. Elger, F. Mormann, T. Kreuz, R. Andrzejak, Christoph Rieke, Robert Sowa, S. Florin, P. David, K. Lehnertz
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Characterizing the spatio-temporal dynamics of the epileptogenic process with nonlinear EEG analyses
In this overview we present our work investigating the spatio-temporal dynamics of the epileptogenic process using time series analysis techniques derived from the theory of nonlinear dynamics. Apart from a localization of epileptic foci in different anatomical locations during the seizure-free interval we discuss possibilities for seizure prediction, a field that represents one of the greatest challenges in epileptology. The unequivocal definition of a pre-seizure state of a sufficient length would enable investigation of basic mechanisms leading to seizure initiation in humans and provide a basis for the development of adequate seizure prevention strategies.