多孔可生物降解储药器体外释药及体内耐受性评价

Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference Pub Date : 1995-04-07 DOI:10.1109/SBEC.1995.514418

D. Yang, G. Peyman, K. Fillacier, B. Khoobehi

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引用次数: 1

摘要

采用生物可降解聚合物聚己内酯作为负载5-羧基荧光素染料的眼内给药装置进行了体外和体内试验。羧基荧光素在体外获得零级释放。该装置植入兔眼后耐受性良好。需要进一步的研究来确定这种给药方式的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Evaluation of in vitro drug release and in vivo tolerance of porous biodegradable reservoir device

The biodegradable polymer polycaprolactone was tested in vitro and in vivo as an intraocular drug delivery device loaded with 5-carboxyfluorescein dye. Zero-order release of carboxyfluorescein was obtained in vitro. The device was tolerated well after implantation in the rabbit eye. Further studies are necessary to determine the efficacy of this form of drug delivery.

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Proceedings of the 1995 Fourteenth Southern Biomedical Engineering Conference

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