Diabetes Secondary to Pancreatic Disease

Diabetes secondary to pancreatic disease accounts for 0.5% of all cases of diabetes mellitus. These conditions are associated with exocrine as well as endocrine pancreatic failure and present a complex management challenge. Diabetes in patients with haemochromatosis is associated with micro- and macrovascular complications and most patients require insulin therapy. Regular venesection to reduce the iron overload is associated with improvements in glycaemic control. Secondary haemochromatosis occurring in patients with haematological conditions requiring frequent blood transfusions is also associated with diabetes. Diabetes secondary to pancreatic disease is commonly seen and can present complex management problems which are best managed by a multidisciplinary team. Treating the underlying condition, as well as the associated hyperglycaemia, is essential.