非瘢痕性(雄激素源性)脱发的常用治疗配方

Jannat AL-JUBOURİ, Leyla BEBA POJARANİ, M. Celi̇k
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摘要

尽管是一种不会危及生命的疾病,但脱发严重影响了有这种经历的人的生活质量。最近的研究表明,全球脱发患者的数量正在上升。雄激素性脱发(AGA)影响所有年龄段的男女。研究发现,遗传因素和家族史对脱发的可能性有很大影响。统计数据显示,在他们的一生中,80%的男性会经历脱发,而40%到50%的女性可能会面临某种形式的脱发。AGA的特点是男性额颞部脱发,女性头皮中线部分头发稀疏。市场上有多种草药配方可用于对抗AGA,而目前fda批准的药物只有两种:口服非那雄胺和外用米诺地尔。非那雄胺的局部配方仍在临床试验中。米诺地尔和非那雄胺制剂为两性提供有效的AGA治疗。最近对这两种药物潜在副作用的关注引起了人们对提供新的创新替代配方(营养素、矿物质和维生素)的兴趣,以提供更安全的治疗AGA。本文提供了当前和替代的AGA配方的简要概述。
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Common Treatment Formulation for Non-Scaring (Androgenetic) Alopecia
In spite of being a non-life-threatening condition, hair loss (alopecia) severely impacts the quality of life of individuals who experience it. Recent studies indicate that the number of patients suffering from alopecia globally is on the rise. Androgenic alopecia (AGA) affects both genders at all ages. Genetic factors and family history are found to greatly impact the likelihood of experiencing hair loss. Statistics reveal that during the course of their lives, 80% of men experience alopecia, while 40 to 50% of women are likely to face some form of hair shedding. AGA is characterized by frontal-temporal hair shedding in men and hair thinning of the midline part of the scalp for women. A variety of herbal formulations are available on the market to combat AGA, while only two FDA-approved medications exist at the moment: oral finasteride and topical minoxidil. Topical formulations of finasteride are still under clinical trials. Minoxidil and finasteride formulations provide effective AGA treatment for both genders. Recent concerns regarding potential side effects of these two medications have drawn interest in providing new innovative alternative formulations (nutrients, minerals and vitamins) to provide a safer treatment against AGA. This article provides a brief overview of the current and alternative AGA formulations.
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