Pub Date : 2024-07-09DOI: 10.54994/emujpharmsci.1508972
Mehmet İlktaç, Zeynep Pelin Kutlu, Yankı Çelebi, Gülden Çelik
Pimpinella species, belonging to Apiaceae (Lindl.) family, utilized in many fields of industry as spice, fruit, vegetable and beverage have especially been used in traditional medicine as a remedy in various countries. Essential oils (EO) of various species including Pimpinella cypria, Pimpinella kotshchyana, Pimpinella saxifraga, and Pimpinella anisum were reported to have antibacterial and antifungal activities. Furthermore, it was observed that P. anisum EO possessed antiviral properties. Along with its antimicrobial activity, Pimpinella species were found to have antioxidant, anti-inflammatory, anticonvulsant, antispasmodic, estrogenic, cytotoxic, insecticidal, and repellent properties. This review aims to provide an enhanced understanding on some Pimpinella species’ morphology, chemical constituent, industrial and medicinal usage, and antimicrobial activities against bacteria, fungi, and viruses.
{"title":"ANTIMICROBIAL ACTIVITY OF PIMPINELLA - AN OVERVIEW","authors":"Mehmet İlktaç, Zeynep Pelin Kutlu, Yankı Çelebi, Gülden Çelik","doi":"10.54994/emujpharmsci.1508972","DOIUrl":"https://doi.org/10.54994/emujpharmsci.1508972","url":null,"abstract":"Pimpinella species, belonging to Apiaceae (Lindl.) family, utilized in many fields of industry as spice, fruit, vegetable and beverage have especially been used in traditional medicine as a remedy in various countries. \u0000Essential oils (EO) of various species including Pimpinella cypria, Pimpinella kotshchyana, Pimpinella saxifraga, and Pimpinella anisum were reported to have antibacterial and antifungal activities. Furthermore, it was observed that P. anisum EO possessed antiviral properties. \u0000Along with its antimicrobial activity, Pimpinella species were found to have antioxidant, anti-inflammatory, anticonvulsant, antispasmodic, estrogenic, cytotoxic, insecticidal, and repellent properties. \u0000This review aims to provide an enhanced understanding on some Pimpinella species’ morphology, chemical constituent, industrial and medicinal usage, and antimicrobial activities against bacteria, fungi, and viruses.","PeriodicalId":351131,"journal":{"name":"EMU Journal of Pharmaceutical Sciences","volume":"46 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141663778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-09DOI: 10.54994/emujpharmsci.1489024
Ibilola Cardoso-daodu, Emmanuel Agbarakwe, M. Ilomuanya, ChukwuemekaPaul Azubuike, Boladale Silva
This study aims to formulate and characterize zinc-loaded hydrogel infused with Aloe barbadensis mucilage for wound dressing. Five formulations containing varying proportions of carbopol, zinc, aloe and water (as vehicle) were developed via physical crosslinking using triethanolamine. All formulations had a translucent off-white colour while the control gave a transparent gel. The viscosity was highest in the control, 30000.00 ± 2.07 PaS. The pH of the formulations was between 5.7 and 5.8. Formulation 2 which is composed of 30 mg of Zinc and 1.4 mg of Aloe barbadensis incorporated into 1% w/v Carbopol Ultrez hydrogel polymer had the lowest swelling index of 79.2 ± 1.95% implying that it had the fastest drug release rate. The wounds treated with Formulation 2 had the most rapid wound healing with no sign of scars in the wound area. Histomorphometric evaluation reflected a high re-epithelisation rate of 70%, a significant percentage occupied by collagen in granulation tissue of 85%. The thickness of the tissue's central region was 10 mm. The inflammatory cells /mm2 tissue was 200 cells/mm2 while the number of microvessels in granulation tissue was 1.0 microvessels/mm2. Zinc-loaded hydrogel infused with Aloe barbadensis mucilage shows great potential as a modern wound dressing.
{"title":"DEVELOPMENT OF ZINC-LOADED HYDROGEL INFUSED WITH ALOE BARBADENSIS MUCILAGE FOR WOUND HEALING","authors":"Ibilola Cardoso-daodu, Emmanuel Agbarakwe, M. Ilomuanya, ChukwuemekaPaul Azubuike, Boladale Silva","doi":"10.54994/emujpharmsci.1489024","DOIUrl":"https://doi.org/10.54994/emujpharmsci.1489024","url":null,"abstract":"This study aims to formulate and characterize zinc-loaded hydrogel infused with Aloe barbadensis mucilage for wound dressing. Five formulations containing varying proportions of carbopol, zinc, aloe and water (as vehicle) were developed via physical crosslinking using triethanolamine. All formulations had a translucent off-white colour while the control gave a transparent gel. The viscosity was highest in the control, 30000.00 ± 2.07 PaS. The pH of the formulations was between 5.7 and 5.8. Formulation 2 which is composed of 30 mg of Zinc and 1.4 mg of Aloe barbadensis incorporated into 1% w/v Carbopol Ultrez hydrogel polymer had the lowest swelling index of 79.2 ± 1.95% implying that it had the fastest drug release rate. The wounds treated with Formulation 2 had the most rapid wound healing with no sign of scars in the wound area. Histomorphometric evaluation reflected a high re-epithelisation rate of 70%, a significant percentage occupied by collagen in granulation tissue of 85%. The thickness of the tissue's central region was 10 mm. The inflammatory cells /mm2 tissue was 200 cells/mm2 while the number of microvessels in granulation tissue was 1.0 microvessels/mm2. Zinc-loaded hydrogel infused with Aloe barbadensis mucilage shows great potential as a modern wound dressing.","PeriodicalId":351131,"journal":{"name":"EMU Journal of Pharmaceutical Sciences","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141664962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-09DOI: 10.54994/emujpharmsci.1503153
Açelya Mavideniz, Tuğba Erçetin, Aybike Yektaoglu, Zahra Nobavar, Jale Yuzugulen, Emine Dilek Özyılmaz, H. O. Gülcan
Cholinesterase inhibition has gained attention in the treatment of some disease states, covering cholinergic deficiency. Alzheimer’s disease (AD) can be counted as the most important one among them. Indeed, the current drugs used in the treatment of AD are cholinesterase inhibitor molecules, besides memantine, and biological new drugs. Many pharmacophores have been suggested so far for cholinesterase inhibition and many of them possess a basic center with an amine function. Within this work, we have selected some simple amines and investigated their potential to inhibit acetylcholinesterase and butyrylcholinesterase enzymes. The results indicated that simple amines by themselves don’t have strong potential unless they are used with other pharmacophores.
{"title":"Screening cholinesterase inhibitory potential of selected amines","authors":"Açelya Mavideniz, Tuğba Erçetin, Aybike Yektaoglu, Zahra Nobavar, Jale Yuzugulen, Emine Dilek Özyılmaz, H. O. Gülcan","doi":"10.54994/emujpharmsci.1503153","DOIUrl":"https://doi.org/10.54994/emujpharmsci.1503153","url":null,"abstract":"Cholinesterase inhibition has gained attention in the treatment of some disease states, covering cholinergic deficiency. Alzheimer’s disease (AD) can be counted as the most important one among them. Indeed, the current drugs used in the treatment of AD are cholinesterase inhibitor molecules, besides memantine, and biological new drugs. Many pharmacophores have been suggested so far for cholinesterase inhibition and many of them possess a basic center with an amine function. Within this work, we have selected some simple amines and investigated their potential to inhibit acetylcholinesterase and butyrylcholinesterase enzymes. The results indicated that simple amines by themselves don’t have strong potential unless they are used with other pharmacophores.","PeriodicalId":351131,"journal":{"name":"EMU Journal of Pharmaceutical Sciences","volume":"71 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141664540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-09DOI: 10.54994/emujpharmsci.1506675
Ertuğrul Özbil, Sultan Öğmen Seven, Açelya Mavideniz, Mehmet İlktaç
Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), works by reducing hormones for the treatment of fever, inflammation, and pain. Previously, it was only shown that the Ibuprofen inhibits the effect of various bacteria that are stimulated by bacterial infections and not directly on bacterial cells. In this study, we aimed to investigate antibacterial and synergistic activities of Ibuprofen against Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922 and Klebsiella pneumoniae ATCC 700603. The results revealed promising antibacterial activity against tested Gram-positive bacteria, but there was no effect on Gram-negative bacteria. Furthermore, checkerboard assays did not reveal any additive or synergistic activity when combined with ciprofloxacin against tested Gram-positive bacteria. Collectively, our data reveal the selective antibacterial activity of ibuprofen against Gram-positive bacteria which suggests that ibuprofen can be further investigated as a potential source for new therapeutic options.
{"title":"Antibacterial potency of Ibuprofen and its interaction with ciprofloxacin against Gram positive and Gram negative bacteria","authors":"Ertuğrul Özbil, Sultan Öğmen Seven, Açelya Mavideniz, Mehmet İlktaç","doi":"10.54994/emujpharmsci.1506675","DOIUrl":"https://doi.org/10.54994/emujpharmsci.1506675","url":null,"abstract":"Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), works by reducing hormones for the treatment of fever, inflammation, and pain. Previously, it was only shown that the Ibuprofen inhibits the effect of various bacteria that are stimulated by bacterial infections and not directly on bacterial cells. In this study, we aimed to investigate antibacterial and synergistic activities of Ibuprofen against Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922 and Klebsiella pneumoniae ATCC 700603. The results revealed promising antibacterial activity against tested Gram-positive bacteria, but there was no effect on Gram-negative bacteria. Furthermore, checkerboard assays did not reveal any additive or synergistic activity when combined with ciprofloxacin against tested Gram-positive bacteria. Collectively, our data reveal the selective antibacterial activity of ibuprofen against Gram-positive bacteria which suggests that ibuprofen can be further investigated as a potential source for new therapeutic options.","PeriodicalId":351131,"journal":{"name":"EMU Journal of Pharmaceutical Sciences","volume":"94 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141664224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-09DOI: 10.54994/emujpharmsci.1506693
Sultan Öğmen Seven, Ertuğrul Özbil, Açelya Mavideniz, Mehmet İlktaç
Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), is commonly used to reduce fever, and to treat pain and inflammation caused by several conditions. Previously, naproxen was evaluated for its antimicrobial potency in various studies. In our study, we aimed to demonstrate the antibacterial and synergistic activities of naproxen and ciprofloxacin against various Gram-positive and Gram-negative bacteria including, Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922 and Klebsiella pneumoniae ATCC 700603. The results showed promising antibacterial activity against tested Gram-positive bacteria. However, there was no effect on Gram-negative bacteria. Additionally, checkerboard assays did not reveal any additive or synergistic activity when combined with Ciprofloxacin. Collectively, our study's data show naproxen's selectivity against Gram-positive bacteria. This result suggests that naproxen can be further used as a potential source of antibiotics against Gram-positive bacteria.
{"title":"In vitro antibacterial acitivity of Naproxen and its combination with ciprofloxacin","authors":"Sultan Öğmen Seven, Ertuğrul Özbil, Açelya Mavideniz, Mehmet İlktaç","doi":"10.54994/emujpharmsci.1506693","DOIUrl":"https://doi.org/10.54994/emujpharmsci.1506693","url":null,"abstract":"Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), is commonly used to reduce fever, and to treat pain and inflammation caused by several conditions. Previously, naproxen was evaluated for its antimicrobial potency in various studies. In our study, we aimed to demonstrate the antibacterial and synergistic activities of naproxen and ciprofloxacin against various Gram-positive and Gram-negative bacteria including, Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922 and Klebsiella pneumoniae ATCC 700603. The results showed promising antibacterial activity against tested Gram-positive bacteria. However, there was no effect on Gram-negative bacteria. Additionally, checkerboard assays did not reveal any additive or synergistic activity when combined with Ciprofloxacin. Collectively, our study's data show naproxen's selectivity against Gram-positive bacteria. This result suggests that naproxen can be further used as a potential source of antibiotics against Gram-positive bacteria.","PeriodicalId":351131,"journal":{"name":"EMU Journal of Pharmaceutical Sciences","volume":"30 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141664835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-21DOI: 10.54994/emujpharmsci.1196909
M. Eissa
To guarantee that patients receive safe therapy with predictable and acceptable medicinal properties, monitoring the quality standards in the healthcare sector and the pharmaceutical business, in particular, is essential. Medicinal products are no exception from these crucial characteristics and hence mitigation of the sources of microbial contamination is a mandatory strategy to avoid harming already-ill populations. Machines, equipment and tools that are used in the industry must be appropriately cleaned to ensure that they will not contaminate the product under processing. The study herein aimed to establish an evaluation system for cleaning efficiency through the rinse technique using Statistical Process Control (SPC) methodologies. A database was established and created for the recorded cleaning process over 20 months of the monitoring period. The control charts were constructed and evaluated from processed data using SPC software. A rare event control chart was used to track the cleaning process intervals with event probability estimated to be 0.080. Concerning the monitoring of the bioburden of rinse samples, the most appropriate fitting attribute chart is U type with Laney modification of over-dispersion to correct for tight control limits that increase alarming false points. Understanding the inspection property is inevitable for the right interpretation of trends.
{"title":"Evaluation of Microbiological Cleanliness of Machines/Equipment through Rinse Technique Using Statistical Process Control","authors":"M. Eissa","doi":"10.54994/emujpharmsci.1196909","DOIUrl":"https://doi.org/10.54994/emujpharmsci.1196909","url":null,"abstract":"To guarantee that patients receive safe therapy with predictable and acceptable medicinal properties, monitoring the quality standards in the healthcare sector and the pharmaceutical business, in particular, is essential. Medicinal products are no exception from these crucial characteristics and hence mitigation of the sources of microbial contamination is a mandatory strategy to avoid harming already-ill populations. Machines, equipment and tools that are used in the industry must be appropriately cleaned to ensure that they will not contaminate the product under processing. The study herein aimed to establish an evaluation system for cleaning efficiency through the rinse technique using Statistical Process Control (SPC) methodologies. A database was established and created for the recorded cleaning process over 20 months of the monitoring period. The control charts were constructed and evaluated from processed data using SPC software. A rare event control chart was used to track the cleaning process intervals with event probability estimated to be 0.080. Concerning the monitoring of the bioburden of rinse samples, the most appropriate fitting attribute chart is U type with Laney modification of over-dispersion to correct for tight control limits that increase alarming false points. Understanding the inspection property is inevitable for the right interpretation of trends.","PeriodicalId":351131,"journal":{"name":"EMU Journal of Pharmaceutical Sciences","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115743726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matrix tablets were prepared by three different polymers as sustained-release agents, using Glibenclamide as a model drug. The aim of the present study was to formulate and evaluate the controlled release matrix tablets of Glibenclamide which is an antidiabetic drug which belongs to the second generation oral hypoglycemics. Three polymers were selected for this study- HPMC K 15, HPMC K 100 and EC in different drug: polymer ratio. The drug was identified by FTIR spectroscopic method. The pre compression and post compression parameters of all formulations were found to be within acceptable limit. The release rate of Glibenclamide from matrix tablets was studied using USP Dissolution Testing Apparatus type-I (Basket method). The formulation F6 which contained EC 50mg showed a maximum release of 99.28% in 24 hrs and revealed that EC was more effective in sustaining the drug release and therefore the formulation F6 selected as the optimized formulation. The in-vitro release data of optimized formulation was fit into various kinetic models, among the different models data of in-vitro release of best fit into Zero order kinetic model. The formulation best fit to Higuchi model showed that drug release from the prepared matrix tablets occurs via diffusion process.
{"title":"Formulation development and evaluation of controlled release matrix tablets of glibenclamide","authors":"Biji Palatty, Praveena Raj, Daiay Pa, Boby JOHNS .G","doi":"10.54994/emujpharmsci.1215120","DOIUrl":"https://doi.org/10.54994/emujpharmsci.1215120","url":null,"abstract":"Matrix tablets were prepared by three different polymers as sustained-release agents, using Glibenclamide as a model drug. The aim of the present study was to formulate and evaluate the controlled release matrix tablets of Glibenclamide which is an antidiabetic drug which belongs to the second generation oral hypoglycemics. Three polymers were selected for this study- HPMC K 15, HPMC K 100 and EC in different drug: polymer ratio. The drug was identified by FTIR spectroscopic method. The pre compression and post compression parameters of all formulations were found to be within acceptable limit. The release rate of Glibenclamide from matrix tablets was studied using USP Dissolution Testing Apparatus type-I (Basket method). The formulation F6 which contained EC 50mg showed a maximum release of 99.28% in 24 hrs and revealed that EC was more effective in sustaining the drug release and therefore the formulation F6 selected as the optimized formulation. The in-vitro release data of optimized formulation was fit into various kinetic models, among the different models data of in-vitro release of best fit into Zero order kinetic model. The formulation best fit to Higuchi model showed that drug release from the prepared matrix tablets occurs via diffusion process.","PeriodicalId":351131,"journal":{"name":"EMU Journal of Pharmaceutical Sciences","volume":"14 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124275315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-26DOI: 10.54994/emujpharmsci.1202754
Derya Doğanay, Şevval Maral ÖZCAN AYKOL, A. Şentürk, S. Ölgen
Objectives:Increasing antibiotic resistance is an important problem for public health therefore new antimicrobial compounds are needed. In this study, the antimicrobial effect of 3-Substituted Indole-2-one and -thione derivatives was investigated. Methods: Antimicrobial effects of previously synthesized 18 different 3-substituted indole-2-one and 2-thione derivatives against 5 different microorganisms were investigated and the structure-activity relationships and drug-like properties of compounds were analyzed by molecular docking and in silico prediction studies.The in vitro antimicrobial activities of compounds were tested by microdilution method. Results:The most active compounds 2, 3, 4, 5, 6, 7 and 8 showed antimicrobial activity at 125 μg/mL of MIC value comparable to reference compound ampicillin. Compounds 2 and 3 were found to be active against S. enterica and compounds 4, 5, 6, 7, and 8 were found to be active against methicillin-resistant S. aureus (MRSA). According to molecular docking studies, all compounds presented weaker binding properties than ciprofloxacin, ampicillin and gentamicin. The predicted values for molecular weight, log P, PSA, crossing the BBB, GI absorption properties and type of CYPP450 inhibition data of compounds were found promising for drug-like properties. Conclusions: 3-Substituted Indole-2-one and -thione derivatives can proivide an important contribution to develop alternative antimicrobial agents.
{"title":"Antimicrobial Activity Studies of 3-Substituted Indole-2-one and -thione derivatives and Molecular Docking and ADME Evaluations","authors":"Derya Doğanay, Şevval Maral ÖZCAN AYKOL, A. Şentürk, S. Ölgen","doi":"10.54994/emujpharmsci.1202754","DOIUrl":"https://doi.org/10.54994/emujpharmsci.1202754","url":null,"abstract":"Objectives:Increasing antibiotic resistance is an important problem for public health therefore new antimicrobial compounds are needed. In this study, the antimicrobial effect of 3-Substituted Indole-2-one and -thione derivatives was investigated. \u0000Methods: Antimicrobial effects of previously synthesized 18 different 3-substituted indole-2-one and 2-thione derivatives against 5 different microorganisms were investigated and the structure-activity relationships and drug-like properties of compounds were analyzed by molecular docking and in silico prediction studies.The in vitro antimicrobial activities of compounds were tested by microdilution method. \u0000Results:The most active compounds 2, 3, 4, 5, 6, 7 and 8 showed antimicrobial activity at 125 μg/mL of MIC value comparable to reference compound ampicillin. Compounds 2 and 3 were found to be active against S. enterica and compounds 4, 5, 6, 7, and 8 were found to be active against methicillin-resistant S. aureus (MRSA). According to molecular docking studies, all compounds presented weaker binding properties than ciprofloxacin, ampicillin and gentamicin. The predicted values for molecular weight, log P, PSA, crossing the BBB, GI absorption properties and type of CYPP450 inhibition data of compounds were found promising for drug-like properties. \u0000Conclusions: 3-Substituted Indole-2-one and -thione derivatives can proivide an important contribution to develop alternative antimicrobial agents.","PeriodicalId":351131,"journal":{"name":"EMU Journal of Pharmaceutical Sciences","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123576850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-24DOI: 10.54994/emujpharmsci.1211611
Jannat AL-JUBOURİ, Leyla BEBA POJARANİ, M. Celi̇k
In spite of being a non-life-threatening condition, hair loss (alopecia) severely impacts the quality of life of individuals who experience it. Recent studies indicate that the number of patients suffering from alopecia globally is on the rise. Androgenic alopecia (AGA) affects both genders at all ages. Genetic factors and family history are found to greatly impact the likelihood of experiencing hair loss. Statistics reveal that during the course of their lives, 80% of men experience alopecia, while 40 to 50% of women are likely to face some form of hair shedding. AGA is characterized by frontal-temporal hair shedding in men and hair thinning of the midline part of the scalp for women. A variety of herbal formulations are available on the market to combat AGA, while only two FDA-approved medications exist at the moment: oral finasteride and topical minoxidil. Topical formulations of finasteride are still under clinical trials. Minoxidil and finasteride formulations provide effective AGA treatment for both genders. Recent concerns regarding potential side effects of these two medications have drawn interest in providing new innovative alternative formulations (nutrients, minerals and vitamins) to provide a safer treatment against AGA. This article provides a brief overview of the current and alternative AGA formulations.
{"title":"Common Treatment Formulation for Non-Scaring (Androgenetic) Alopecia","authors":"Jannat AL-JUBOURİ, Leyla BEBA POJARANİ, M. Celi̇k","doi":"10.54994/emujpharmsci.1211611","DOIUrl":"https://doi.org/10.54994/emujpharmsci.1211611","url":null,"abstract":"In spite of being a non-life-threatening condition, hair loss (alopecia) severely impacts the quality of life of individuals who experience it. Recent studies indicate that the number of patients suffering from alopecia globally is on the rise. Androgenic alopecia (AGA) affects both genders at all ages. Genetic factors and family history are found to greatly impact the likelihood of experiencing hair loss. Statistics reveal that during the course of their lives, 80% of men experience alopecia, while 40 to 50% of women are likely to face some form of hair shedding. AGA is characterized by frontal-temporal hair shedding in men and hair thinning of the midline part of the scalp for women. A variety of herbal formulations are available on the market to combat AGA, while only two FDA-approved medications exist at the moment: oral finasteride and topical minoxidil. Topical formulations of finasteride are still under clinical trials. Minoxidil and finasteride formulations provide effective AGA treatment for both genders. Recent concerns regarding potential side effects of these two medications have drawn interest in providing new innovative alternative formulations (nutrients, minerals and vitamins) to provide a safer treatment against AGA. This article provides a brief overview of the current and alternative AGA formulations.","PeriodicalId":351131,"journal":{"name":"EMU Journal of Pharmaceutical Sciences","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127548221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-16DOI: 10.54994/emujpharmsci.1211796
H. O. Gülcan
The research studies worldwide on the identification of novel molecules having the potential to inhibit cholinesterase enzymes generated many compounds with promising results for some of them. With respect to the limited number of drugs corresponding to the central nervous system active cholinesterase inhibitory potential, these research studies continue. Within the scope of this study, four 2-phenoxy-N-substituted-acetamide derivatives were synthesized and their structures were identified employing spectroscopic techniques. The title molecules were further evaluated for their cholinesterase inhibitory potential in modified Ellman’s method. The results displayed that the compounds have moderate activity and the simple scaffold employed might be used in future studies for more promising compounds.
{"title":"Synthesis and cholinesterase inhibitory potential of 2-phenoxy-N-substituted-acetamide derivatives","authors":"H. O. Gülcan","doi":"10.54994/emujpharmsci.1211796","DOIUrl":"https://doi.org/10.54994/emujpharmsci.1211796","url":null,"abstract":"The research studies worldwide on the identification of novel molecules having the potential to inhibit cholinesterase enzymes generated many compounds with promising results for some of them. With respect to the limited number of drugs corresponding to the central nervous system active cholinesterase inhibitory potential, these research studies continue. Within the scope of this study, four 2-phenoxy-N-substituted-acetamide derivatives were synthesized and their structures were identified employing spectroscopic techniques. The title molecules were further evaluated for their cholinesterase inhibitory potential in modified Ellman’s method. The results displayed that the compounds have moderate activity and the simple scaffold employed might be used in future studies for more promising compounds.","PeriodicalId":351131,"journal":{"name":"EMU Journal of Pharmaceutical Sciences","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127040335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：