卡瑞拉嗪作为治疗帕金森病精神病的药物替代品

Q4 Medicine Psiquiatria Biologica Pub Date : 2022-01-01 DOI:10.1016/j.psiq.2021.100347

Javier Vilches Vázquez , Jose Manuel Gallego Rodríguez

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引用次数: 0

摘要

帕金森病(PD)经常表现为精神病症状的并发症。目的描述pd相关精神病症状的治疗过程，评价可能的药物替代方案。临床病例:41岁女性，早期诊断为PD(早期诊断)，对多巴胺能治疗反应差，存在精神病症状，需要深部脑刺激器。患者因服用低剂量左旋多巴后出现新发精神病症状而入院。结果氯氮平治疗效果不佳后，改用卡吡嗪治疗，症状改善，耐受性好，无不良反应。结论氯氮平治疗失败后可选用卡立嗪。

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Cariprazina como alternativa farmacológica en el tratamiento de la psicosis en la enfermedad de Parkinson

Introduction

Parkinson's disease (PD) frequently presents as a complication with the presence of psychotic symptoms.

Objective

To describe the therapeutic process of PD-related psychotic symptoms, evaluating possible pharmacological alternatives.

Clinical case

A 41-year-old woman with early diagnosis of PD (diagnosed at an early age), poor response to dopaminergic treatment, with the presence of psychotic symptoms and the need for a deep brain stimulator. The patient was admitted due to new onset of psychotic symptoms while on low-dose levodopa.

Result

After poor response to treatment with clozapine, cariprazine was tried with improvement of symptoms, good tolerability, and no side effects.

Conclusions

Cariprazine may be an alternative in the event of clozapine treatment failure.

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来源期刊

Psiquiatria Biologica Medicine-Psychiatry and Mental Health

CiteScore

0.40

自引率

0.00%

发文量

期刊介绍： Es la Publicación Oficial de la Sociedad Española de Psiquiatría Biológica. Los recientes avances en el conocimiento de la bioquímica y de la fisiología cerebrales y el progreso en general en el campo de las neurociencias han abierto el camino al desarrollo de la psiquiatría biológica, fundada sobre bases anatomofisiológicas, más sólidas y científicas que la psiquiatría tradicional.

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