辛伐他汀对皮质类固醇诱导大鼠骨髓脂质肥厚的影响

Liszt Palmeira de Oliveira, Luiz Otavio Sampaio Penteado, J. Carvalho, K. C. Mesquita
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摘要

目的:探讨辛伐他汀(SV)对氢化可的松(HC)所致大鼠股骨头脂肪细胞占据区(MAOA)的影响。方法:将40只雄性褐家鼠(Rattus norvegicus albinos)分为5组,每组8只,按每天15 d的给药剂量:HC (25 mg)、HC (25 mg) + SB、HC (1 mg)、HC (1 mg) + SV、生理盐水(SF)。治疗前后分别进行血清甘油三酯(TRI)、总胆固醇(COL)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)检测。形态学测定股骨头MAOA。结果:各组大鼠实验开始时血清TRI、COL、AST、ALT值差异无统计学意义。与接受SF的动物相比,接受HC的动物有更高的MAOA (p < 0.0001),血清TRI和COL读数有统计学意义的增加。HC组的MAOA高于JC + SV组(p < 0.0001)。在HC (1 mg) + SV治疗组中,治疗后血清TRI值(p = 0.1907)和COL值(p = 0.4480)与SF组相比,MAOA无显著差异(p = 0.5047)。在接受HC (25 mg) + SV治疗的动物中,与接受SF治疗的动物相比,MAOA (p < 0.0001)以及治疗后血清TRI (p = 0.0044)和COL (p = 0.0025)的读数存在显著差异。各组血清谷丙转氨酶和谷丙转氨酶水平均升高。HC的使用与股骨头髓质脂肪细胞占据面积较大有关,且与给药剂量成正比。使用辛伐他汀后,这种效应减弱。结论:辛伐他汀对降低HC诱导的骨髓质脂含量有显著作用,且在低剂量组更为一致。
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EFEITOS DA SINVASTATINA NA HIPERTROFIA LIPÍDICA DA MEDULA ÓSSEA INDUZIDA PELO USO DE CORTICÓIDES EM RATOS
OBJECTIVES: To evaluate the effects of using simvastatin (SV) on the medullary area occupied by adipocytes (MAOA) in the femoral head of rats with lipidic hypertrophy induced by hydrocortisone (HC). METHODS: 40 male Wistar rats (Rattus norvegicus albinos) were distributed into five groups, each group with eight animals, according to the medication given daily during 15 days: HC (25 mg), HC (25 mg) + SB, HC (1 mg), HC (1 mg) + SV, and saline solution (SF). Serum triglyceride (TRI), total cholesterol (COL), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) tests were performed before and after treatment. Femoral head MAOA was determined by morphometry. RESULTS: the groups had similar results of serum values of TRI, COL, AST, and ALT in the beginning of the experiment. The animals that received HC had greater MAOA when compared to those receiving SF (p < 0.0001), with statistically significant increases in the serum TRI and COL readings. MAOA was greater in the groups receiving HC than in the groups receiving JC + SV (p < 0.0001). In the group that received HC (1 mg) + SV, there was no significant difference in MAOA, when compared to the group that received SF (p = 0.5047), nor in the serum values of TRI (p = 0.1907) and COL (p = 0.4480), after the treatment. In the animals that received HC (25 mg) + SV, there was a significant difference in MAOA, when compared to the group that received SF (p < 0.0001), and in the serum readings of TRI (p = 0.0044) and COL (p = 0.0025), after the treatment. All groups presented increased serum levels of AST and ALT. The use of HC was related to a larger area occupied by adipocytes in the medulla of the femoral head, which was directly proportional to the dose given. This effect was reduced with the use of simvastatin. CONCLUSION: The use of simvastatin to reduce the bone medulla lipidic content induced by HC was significant, and more consistent in the group treated with low HC doses.
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