Pub Date : 2007-12-01DOI: 10.1590/S0102-36162007001100005
Liszt Palmeira de Oliveira, Luiz Otavio Sampaio Penteado, J. Carvalho, K. C. Mesquita
OBJECTIVES: To evaluate the effects of using simvastatin (SV) on the medullary area occupied by adipocytes (MAOA) in the femoral head of rats with lipidic hypertrophy induced by hydrocortisone (HC). METHODS: 40 male Wistar rats (Rattus norvegicus albinos) were distributed into five groups, each group with eight animals, according to the medication given daily during 15 days: HC (25 mg), HC (25 mg) + SB, HC (1 mg), HC (1 mg) + SV, and saline solution (SF). Serum triglyceride (TRI), total cholesterol (COL), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) tests were performed before and after treatment. Femoral head MAOA was determined by morphometry. RESULTS: the groups had similar results of serum values of TRI, COL, AST, and ALT in the beginning of the experiment. The animals that received HC had greater MAOA when compared to those receiving SF (p < 0.0001), with statistically significant increases in the serum TRI and COL readings. MAOA was greater in the groups receiving HC than in the groups receiving JC + SV (p < 0.0001). In the group that received HC (1 mg) + SV, there was no significant difference in MAOA, when compared to the group that received SF (p = 0.5047), nor in the serum values of TRI (p = 0.1907) and COL (p = 0.4480), after the treatment. In the animals that received HC (25 mg) + SV, there was a significant difference in MAOA, when compared to the group that received SF (p < 0.0001), and in the serum readings of TRI (p = 0.0044) and COL (p = 0.0025), after the treatment. All groups presented increased serum levels of AST and ALT. The use of HC was related to a larger area occupied by adipocytes in the medulla of the femoral head, which was directly proportional to the dose given. This effect was reduced with the use of simvastatin. CONCLUSION: The use of simvastatin to reduce the bone medulla lipidic content induced by HC was significant, and more consistent in the group treated with low HC doses.
{"title":"EFEITOS DA SINVASTATINA NA HIPERTROFIA LIPÍDICA DA MEDULA ÓSSEA INDUZIDA PELO USO DE CORTICÓIDES EM RATOS","authors":"Liszt Palmeira de Oliveira, Luiz Otavio Sampaio Penteado, J. Carvalho, K. C. Mesquita","doi":"10.1590/S0102-36162007001100005","DOIUrl":"https://doi.org/10.1590/S0102-36162007001100005","url":null,"abstract":"OBJECTIVES: To evaluate the effects of using simvastatin (SV) on the medullary area occupied by adipocytes (MAOA) in the femoral head of rats with lipidic hypertrophy induced by hydrocortisone (HC). METHODS: 40 male Wistar rats (Rattus norvegicus albinos) were distributed into five groups, each group with eight animals, according to the medication given daily during 15 days: HC (25 mg), HC (25 mg) + SB, HC (1 mg), HC (1 mg) + SV, and saline solution (SF). Serum triglyceride (TRI), total cholesterol (COL), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) tests were performed before and after treatment. Femoral head MAOA was determined by morphometry. RESULTS: the groups had similar results of serum values of TRI, COL, AST, and ALT in the beginning of the experiment. The animals that received HC had greater MAOA when compared to those receiving SF (p < 0.0001), with statistically significant increases in the serum TRI and COL readings. MAOA was greater in the groups receiving HC than in the groups receiving JC + SV (p < 0.0001). In the group that received HC (1 mg) + SV, there was no significant difference in MAOA, when compared to the group that received SF (p = 0.5047), nor in the serum values of TRI (p = 0.1907) and COL (p = 0.4480), after the treatment. In the animals that received HC (25 mg) + SV, there was a significant difference in MAOA, when compared to the group that received SF (p < 0.0001), and in the serum readings of TRI (p = 0.0044) and COL (p = 0.0025), after the treatment. All groups presented increased serum levels of AST and ALT. The use of HC was related to a larger area occupied by adipocytes in the medulla of the femoral head, which was directly proportional to the dose given. This effect was reduced with the use of simvastatin. CONCLUSION: The use of simvastatin to reduce the bone medulla lipidic content induced by HC was significant, and more consistent in the group treated with low HC doses.","PeriodicalId":231226,"journal":{"name":"Ciência Animal e Veterinária: inovações e tendências","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128184383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. A. R. Rossi, Marcelo Soares, Matheus Schardong Lucca, M. S. Ceron, V. de Oliveira, B. N. Fraga
{"title":"USO DE ÓLEOS ESSENCIAIS NO CONTROLE DOS SINAIS CLÍNICOS DAS DIARREIAS NEONATAIS EM LEITÕES NASCIDOS DE FÊMEAS COM DIFERENTES ORDENS DE PARTO","authors":"C. A. R. Rossi, Marcelo Soares, Matheus Schardong Lucca, M. S. Ceron, V. de Oliveira, B. N. Fraga","doi":"10.37885/211106573","DOIUrl":"https://doi.org/10.37885/211106573","url":null,"abstract":"","PeriodicalId":231226,"journal":{"name":"Ciência Animal e Veterinária: inovações e tendências","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124763942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan Carlos Palomino Quintero, L. Calixto, A. J. Almeida, Yuri Rodrigues Moreira, Samuel Queiroz Souza Rocha, Domingos Sávio Sarmet Moreira Smiderle, Karoll Andrea Alfonso Torres-Cordido
{"title":"DESEMPENHO PRODUTIVO DE EMUS REPRODUTORES DE DIFERENTES IDADES, CRIADOS EM CATIVEIRO EM CAMPOS DOS GOYTACAZES-RJ, BRASIL","authors":"Juan Carlos Palomino Quintero, L. Calixto, A. J. Almeida, Yuri Rodrigues Moreira, Samuel Queiroz Souza Rocha, Domingos Sávio Sarmet Moreira Smiderle, Karoll Andrea Alfonso Torres-Cordido","doi":"10.37885/211106807","DOIUrl":"https://doi.org/10.37885/211106807","url":null,"abstract":"","PeriodicalId":231226,"journal":{"name":"Ciência Animal e Veterinária: inovações e tendências","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131011175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jarbas Freitas Amarante, Lilian Kolling, Andreia Ines Ferroato, Mateus Matiuzzi da Costa, T. Amarante
{"title":"RESISTÊNCIA AOS ANTIMICROBIANOS DE BACTÉRIAS OBTIDAS DECARPAS (CYPRINUS CARPIO) CULTIVADAS EM SISTEMA SEMI-INTENSIVO","authors":"Jarbas Freitas Amarante, Lilian Kolling, Andreia Ines Ferroato, Mateus Matiuzzi da Costa, T. Amarante","doi":"10.37885/211106599","DOIUrl":"https://doi.org/10.37885/211106599","url":null,"abstract":"","PeriodicalId":231226,"journal":{"name":"Ciência Animal e Veterinária: inovações e tendências","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122270312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mysterdanes Pires do Nascimento, H. P. Bastos, Antônia Leidiana Moreira, Kelciane Soares de Oliveira, Karine Rocha Mendonça, Karoline Rocha Mendonça, Marlei Rosa dos Santos, Rosadalia Cardoso de Sousa, T. Silva
{"title":"MILHETO EM DIETAS PARA FRANGOS CAIPIRA NO PERIODO DE 1 A 26 DIAS DE IDADE","authors":"Mysterdanes Pires do Nascimento, H. P. Bastos, Antônia Leidiana Moreira, Kelciane Soares de Oliveira, Karine Rocha Mendonça, Karoline Rocha Mendonça, Marlei Rosa dos Santos, Rosadalia Cardoso de Sousa, T. Silva","doi":"10.37885/211106622","DOIUrl":"https://doi.org/10.37885/211106622","url":null,"abstract":"","PeriodicalId":231226,"journal":{"name":"Ciência Animal e Veterinária: inovações e tendências","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117126032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anndreisa Christiny Monteiro, Antonio Waldir Cunha da Silva
{"title":"CIÊNCIA E SOCIEDADE: UMA REVISÃO DA ABORDAGEM ÉTICA NAS QUESTÕES DE EXPERIMENTAÇÃO ANIMAL","authors":"Anndreisa Christiny Monteiro, Antonio Waldir Cunha da Silva","doi":"10.37885/211106750","DOIUrl":"https://doi.org/10.37885/211106750","url":null,"abstract":"","PeriodicalId":231226,"journal":{"name":"Ciência Animal e Veterinária: inovações e tendências","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130593353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. C. Rangel, A. Oliveira, Fernando Vicentini, João Luiz Rossi Jr, Débora Meneses Souza, Carliane Nogueira dos Passos, Deborah Jacome Rodrigues, Iago Oliveira de Mello, Franciane Almeida da Silva, F. R. Braga
{"title":"LEVANTAMENTO DA OCORRÊNCIA DE ADENOVÍRUS EM POPULAÇÃO SILVESTRE DE SAGUIS-DA-CARA-BRANCA CALLITHRIX GEOFFROYI (HUMBOLDT, 1812) NO SUDESTE DO BRASIL","authors":"M. C. Rangel, A. Oliveira, Fernando Vicentini, João Luiz Rossi Jr, Débora Meneses Souza, Carliane Nogueira dos Passos, Deborah Jacome Rodrigues, Iago Oliveira de Mello, Franciane Almeida da Silva, F. R. Braga","doi":"10.37885/211206895","DOIUrl":"https://doi.org/10.37885/211206895","url":null,"abstract":"","PeriodicalId":231226,"journal":{"name":"Ciência Animal e Veterinária: inovações e tendências","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128704562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marina Jorge de Lemos, L. Calixto, Guilherme Melgaço Heluy, So yin Nak
{"title":"EFEITO DO PROLONGAMENTO DO CICLO PRODUTIVO DE POEDEIRAS SEMIPESADAS SOBRE A QUALIDADEDE OVOS FRESCOS E ARMAZENADOS","authors":"Marina Jorge de Lemos, L. Calixto, Guilherme Melgaço Heluy, So yin Nak","doi":"10.37885/211106632","DOIUrl":"https://doi.org/10.37885/211106632","url":null,"abstract":"","PeriodicalId":231226,"journal":{"name":"Ciência Animal e Veterinária: inovações e tendências","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121411138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Soares, Filipe Cássio Silva de Lima, Á. Teixeira, S. S. D. Silva, I. Melo, Welma Emídio da Silva
{"title":"HISTOLOGIA RENAL E HEPÁTICA DE RATOS \u0000TREINADOS COM NATAÇÃO SOB TRATAMENTO COM ESTANOZOLOL","authors":"A. Soares, Filipe Cássio Silva de Lima, Á. Teixeira, S. S. D. Silva, I. Melo, Welma Emídio da Silva","doi":"10.37885/211106799","DOIUrl":"https://doi.org/10.37885/211106799","url":null,"abstract":"","PeriodicalId":231226,"journal":{"name":"Ciência Animal e Veterinária: inovações e tendências","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130794595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Camilla Taveira Ducas Duarte, Paulo Sérgio de Arruda Pinto, W. Santos, L. P. Almeida, E. C. Acevedo-Nieto, Tatiane de Oliveira Santos
{"title":"ESTUDO DE PREVALÊNCIA E FATORES DE RISCO ASSOCIADOS A CISTICERCOSE BOVINA E SUÍNA EM TRÊS REGIÕES DO ESTADO DE MINAS GERAIS, BRASIL","authors":"Camilla Taveira Ducas Duarte, Paulo Sérgio de Arruda Pinto, W. Santos, L. P. Almeida, E. C. Acevedo-Nieto, Tatiane de Oliveira Santos","doi":"10.37885/211106606","DOIUrl":"https://doi.org/10.37885/211106606","url":null,"abstract":"","PeriodicalId":231226,"journal":{"name":"Ciência Animal e Veterinária: inovações e tendências","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127709245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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