诊断心血管疾病的代谢组学和基因组标记分析

Z. V. Zharkova, A. Yasenyavskaya, I. B. Nikitina, I. V. Goretova, I. Fedoseev, O. Bashkina, M. Samotrueva
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引用次数: 0

摘要

心血管疾病是人口死亡的主要原因。不幸的是,由于与年龄和其他合并症相关的许多因素导致诊断分类和治疗决策的重大不确定性,心血管疾病及其相关风险往往难以诊断。因此,迫切需要寻找新的生物标志物,以更准确地诊断、评估急性和慢性心血管疾病的风险并提出治疗建议。本文介绍了用于心血管疾病诊断的代谢组学和基因组标记的分析。代谢组学与基因组和蛋白质组学的结合研究可以为心血管疾病的发病机制和寻找和鉴定新的心血管疾病生物标志物提供重要信息。随着新的心血管疾病生物标志物的基础数据,迫切需要进一步研究,以确认其在实际医疗保健中的巨大潜力。
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Analysis of metabolomic and genomic markers for diagnosing cardiovascular diseases
Cardiovascular disease is the leading cause of death in the population. Unfortunately, cardiovascular disease and its associated risks are often difficult to diagnose due to the many factors associated with age and other comorbidities that lead to significant uncertainty in diagnostic classification and therapeutic decision making. Therefore, there is a great need to find new biomarkers for more accurate diagnosis, risk assessment and treatment recommendations for both acute and chronic cardiovascular disease. This article presents an analysis of metabolomic and genomic markers used for the diagnosis of cardiovascular disease. The study of the metabolome in combination with the genome and proteome can provide important information about both the pathogenesis of cardiovascular disease and the ability to search for and identify new cardiovascular disease biomarkers. Along with the fundamental data on new cardiovascular disease biomarkers, there is an urgent need for further research confirming their great potential for practical health care.
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