Experimental assessment of the specific activity of a new dosage form of angiolin in cataract modeling

Age-related cataract is currently the leading cause of incurable blindness in the world and the most common eye disease in people over 60 years. Among all ophthalmic diseases, cataract is about 65%. The following medicines are used to treat cataracts: Oftan Catachrom (Santen AO, Finland), Taufon (Farmak, OAO, Kiev, Ukraine.), Quinax (Alcon -Couvreur, Belgium), Vita-Iodurol (Excelvision AG for Novartis Pharma AG, France/Switzerland), Potassium iodide (OOO “UNIMED PHARMA”, Slovak Republic). Based on the foregoing, it is clear that the range of drugs for the treatment of cataracts is limited, and mainly consists of imported drugs. All of the above opens up new prospects for the creation of new ophthalmic medicines for expanding the range of domestic drugs, namely eye drops with wound healing, reparative, anti-inflammatory effects. Therefore, the aim of our work is to create a new ophthalmic drug based on the original substance Angiolin, which will exhibit anti-inflammatory, wound healing, reparative properties. cataract was reproduced on both eyes of 10 animals (20 eyes) by chemical induction of free radical oxidation of biopolymers of eye tissues according to the D.K. Buyan method, for which 30 μl of a sterile solution of dibromide diquat at a dose of 600 nmol was injected once into the vitreous body. Treatment began from 7 days, when the initial opacity of the lens was formed, and was carried out by instillation of drugs into the conjunctival cavity of the eyes 3 times a day. Results: the course administration of 1% Angiolin eye drops had a significant therapeutic effect in the conditions of chemical cataracts. The use of Angiolin drops reduced the lens opacity of the eye of experimental animals by 43,5%. Findings: 1% Angiolin eye drops ((S) -2,6-diaminohexanoic acid 3-methyl-1,2,4-triazolyl-5-thioacetate) as an active ingredient, exhibit significant anti-inflammatory, wound healing, reparative properties, and also have a high therapeutic effect in the treatment of cataracts.