Heart failure (HF) is a major factor contributing to premature death in patients with established cardiovascular (CV) disease. Current cell therapies of HF based on at least two different approaches, in which stem cell transplantation and extracellular vesicles (EV) received from pre-treated cells, were used. Although in HF restoring cardiac function aimed improve survival is target of cell therapy, it is not yet yielded whether isolated EVs from circulating progenitor cells, induced pluripotent stem cells (iPSCs), human embryonic stem cells-derived CV progenitors (hESC-Pg) would be effective translators of reparative signals for cardiac repair. The short communication is depicted the role of different cell strategies in HF. It has emphasized lack of strong evidence of clinical advantages implanted EVs to human cells to iPSCs in HF requires comparison in large clinical trials.
{"title":"Cellular care and extracellular vesicles therapies of heart failure","authors":"A. Berezin, A. Berezin","doi":"10.12988/bmgt.2019.9510","DOIUrl":"https://doi.org/10.12988/bmgt.2019.9510","url":null,"abstract":"Heart failure (HF) is a major factor contributing to premature death in patients with established cardiovascular (CV) disease. Current cell therapies of HF based on at least two different approaches, in which stem cell transplantation and extracellular vesicles (EV) received from pre-treated cells, were used. Although in HF restoring cardiac function aimed improve survival is target of cell therapy, it is not yet yielded whether isolated EVs from circulating progenitor cells, induced pluripotent stem cells (iPSCs), human embryonic stem cells-derived CV progenitors (hESC-Pg) would be effective translators of reparative signals for cardiac repair. The short communication is depicted the role of different cell strategies in HF. It has emphasized lack of strong evidence of clinical advantages implanted EVs to human cells to iPSCs in HF requires comparison in large clinical trials.","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122763934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim of the study was to determine the levels of endothelial cell biomarkers in patients with stage II of hypertension with varying degrees of arterial hypertension. Methods: In order to carry out the study, a comprehensive examination of 224 patients with HT was conducted, including 126 patients with stage II HT of the 1-3 AH degree and 98 ones with stage I HT of the 1-3 AH degree, who were treated at PI "Zaporizhzhya city clinical hospital No 10" of Zaporizhzhya city Council. Practically healthy individuals were examined on an outpatient basis. To participate in the study, patients had to sign “Voluntary informed consent of the patient to participate in the study” form. Results: The synthesis of endothelin-1 is triggered by vasoactive hormones, hypoxia, active oxygen forms, increased content of low-density lipoproteins, shear stress on the endothelium. Abnormalities of NO-dependent relaxation of arteries in patients with hypertension may be caused due to the following mechanisms: decrease in NO production, its accelerated degradation, the changes in cytoarchitectonics of blood vessels. But the greatest importance in the reduction of endothelium-dependent vasodilation is attached to intracellular oxidative stress: free radical oxidation significantly reduces the production of NO by endothelial cells
{"title":"Endothelial function among patients with hypertension stage II with varying degrees of arterial hypertension","authors":"O. M. Bayduzha","doi":"10.12988/bmgt.2019.936","DOIUrl":"https://doi.org/10.12988/bmgt.2019.936","url":null,"abstract":"Aim of the study was to determine the levels of endothelial cell biomarkers in patients with stage II of hypertension with varying degrees of arterial hypertension. Methods: In order to carry out the study, a comprehensive examination of 224 patients with HT was conducted, including 126 patients with stage II HT of the 1-3 AH degree and 98 ones with stage I HT of the 1-3 AH degree, who were treated at PI \"Zaporizhzhya city clinical hospital No 10\" of Zaporizhzhya city Council. Practically healthy individuals were examined on an outpatient basis. To participate in the study, patients had to sign “Voluntary informed consent of the patient to participate in the study” form. Results: The synthesis of endothelin-1 is triggered by vasoactive hormones, hypoxia, active oxygen forms, increased content of low-density lipoproteins, shear stress on the endothelium. Abnormalities of NO-dependent relaxation of arteries in patients with hypertension may be caused due to the following mechanisms: decrease in NO production, its accelerated degradation, the changes in cytoarchitectonics of blood vessels. But the greatest importance in the reduction of endothelium-dependent vasodilation is attached to intracellular oxidative stress: free radical oxidation significantly reduces the production of NO by endothelial cells","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124429163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The level of interleukin-6 and interleukin-13 was analysed in the blood serum of children with diabetes type 1 from 11 to 17 years old. They divided into three groups: the duration of diabetes less than 1 year (1st group), the duration of diabetes from 1 to 5 years (2nd group) and over 5 years (3rd group). The group of control includes conventionally healthy children. All kids have gone through the detailed clinical examination wich included functional tests to determine the condition of skeletal muscles, such as skeletal muscle strength, muscular tissue loss, functional capability and estimation of the muscular mass. Pathogeneticic mechanism of diabetic myopathy is a result of dysbalance between proand anti-inflammatory interleukins. The first manifestations of diabetic myopathy in children occur after the 5 year of diabetes, but subclinical signs develop over the first years of disease. It appears of muscle strength decrease and violation of its functional capability.
{"title":"The pathogenetic role of pro- and anti- inflammatory cytokines in developing of diabetic myopathy in children","authors":"O. Pashkova, N. Chudova","doi":"10.12988/BMGT.2019.948","DOIUrl":"https://doi.org/10.12988/BMGT.2019.948","url":null,"abstract":"The level of interleukin-6 and interleukin-13 was analysed in the blood serum of children with diabetes type 1 from 11 to 17 years old. They divided into three groups: the duration of diabetes less than 1 year (1st group), the duration of diabetes from 1 to 5 years (2nd group) and over 5 years (3rd group). The group of control includes conventionally healthy children. All kids have gone through the detailed clinical examination wich included functional tests to determine the condition of skeletal muscles, such as skeletal muscle strength, muscular tissue loss, functional capability and estimation of the muscular mass. Pathogeneticic mechanism of diabetic myopathy is a result of dysbalance between proand anti-inflammatory interleukins. The first manifestations of diabetic myopathy in children occur after the 5 year of diabetes, but subclinical signs develop over the first years of disease. It appears of muscle strength decrease and violation of its functional capability.","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123711369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of the study was to estimate the interleukin-22 (IL-22) level in the blood serum of hypertensive patients with abdominal obesity (AO), depending on common carotid arteries (CCA) remodeling presence. Ninety-five subjects: 83 hypertensive patients and 12 healthy controls were examined. The patients were divided into two groups, depending on the presence of AO followed by the division of patients into subgroups depending on the intima-media thickness (IMT). For all patients, the following anthropometric parameters were measured: weight, height, waist circumstances (WC), hip circumstances (HC); the body mass index (BMI) and the waist-to-hip ratio (WC/HC) were calculated. The serum IL-22 level was determined in the patients by means of the Bender Medsystems® Human IL-22 Platinum ELISA kit by immunoassay method. Additionally, the patients underwent an ultrasound examination of carotid arteries. The study revealed that the CCA IMT in hypertensive patients with and without AO compared to the control group were significant differences. Serum IL-22 levels in hypertensive patients with AO having IMT ≥ 0.9 mm was statistically higher as compared with patients having IMT < 0.9 mm. 64 Kateryna Kysylenko and Olga Kovalyova The IL-22 levels in hypertensive patients without AO having IMT < 0.9 mm and having IMT ≥ 0.9 mm were significantly exceeds cytokine level in the control group. The obtained results may indicate that the blood serum IL-22 level is associated with a greater degree of vascular wall damage in hyprtensive patient both with and without AO. Higher IL-22 levels in the groups of hypertensive patients both with and without AO, with normal IMT compared with the control group, probably indicate that elevated blood serum IL-22 content can promote an early affection of the vascular endothelium.
{"title":"Interleukin-22 level and vascular remodeling in patients with hypertension in associated with abdominal obesity","authors":"K. Kysylenko, O. Kovalyova","doi":"10.12988/bmgt.2019.947","DOIUrl":"https://doi.org/10.12988/bmgt.2019.947","url":null,"abstract":"The purpose of the study was to estimate the interleukin-22 (IL-22) level in the blood serum of hypertensive patients with abdominal obesity (AO), depending on common carotid arteries (CCA) remodeling presence. Ninety-five subjects: 83 hypertensive patients and 12 healthy controls were examined. The patients were divided into two groups, depending on the presence of AO followed by the division of patients into subgroups depending on the intima-media thickness (IMT). For all patients, the following anthropometric parameters were measured: weight, height, waist circumstances (WC), hip circumstances (HC); the body mass index (BMI) and the waist-to-hip ratio (WC/HC) were calculated. The serum IL-22 level was determined in the patients by means of the Bender Medsystems® Human IL-22 Platinum ELISA kit by immunoassay method. Additionally, the patients underwent an ultrasound examination of carotid arteries. The study revealed that the CCA IMT in hypertensive patients with and without AO compared to the control group were significant differences. Serum IL-22 levels in hypertensive patients with AO having IMT ≥ 0.9 mm was statistically higher as compared with patients having IMT < 0.9 mm. 64 Kateryna Kysylenko and Olga Kovalyova The IL-22 levels in hypertensive patients without AO having IMT < 0.9 mm and having IMT ≥ 0.9 mm were significantly exceeds cytokine level in the control group. The obtained results may indicate that the blood serum IL-22 level is associated with a greater degree of vascular wall damage in hyprtensive patient both with and without AO. Higher IL-22 levels in the groups of hypertensive patients both with and without AO, with normal IMT compared with the control group, probably indicate that elevated blood serum IL-22 content can promote an early affection of the vascular endothelium.","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125815699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.12988/bmgt.2021.91024
E. Sid
{"title":"Combining biomarkers and TIMI score for prediction of left ventricular systolic dysfunction among patients with STEMI","authors":"E. Sid","doi":"10.12988/bmgt.2021.91024","DOIUrl":"https://doi.org/10.12988/bmgt.2021.91024","url":null,"abstract":"","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121409932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
One of the promising courses in the clinical dentistry is the use of molecular biological markers in patients with periodontal disease. First of all, this is due to the rising trend in the prevalence and risk factors of the disease, which makes relevant finding effective methods for early detection and preventive treatment. 30 patients diagnosed with generalized periodontitis of the I and II degree of severity were selected for the research. In the experimental groups of patients, an immunoassay was used to determine the marker level of bone marrow metabolism (MMP-8) in the oral fluid, in the dynamics of treatment. During the study, the content of this enzyme was found to be indicative of the transformation of the inflammatory process in the gums into the destruction of the alveolar bone. 20 A. Yu. Lukash et al. The obtained values of the concentration of MMP-8 in the oral fluid, as well as their dynamics, proved this marker to be indicative of the course of the inflammatory-destructive process in periodontal tissues, and therefore the possibility of its application for the diagnosis and monitoring of the results of treatment of generalized periodontitis
{"title":"Dynamics of markers of bone resorption in oral fluid in patients with generalized parodontitis during its treatment","authors":"A. Y. Lukash, O. Fastovets, S. Pavlov","doi":"10.12988/bmgt.2019.914","DOIUrl":"https://doi.org/10.12988/bmgt.2019.914","url":null,"abstract":"One of the promising courses in the clinical dentistry is the use of molecular biological markers in patients with periodontal disease. First of all, this is due to the rising trend in the prevalence and risk factors of the disease, which makes relevant finding effective methods for early detection and preventive treatment. 30 patients diagnosed with generalized periodontitis of the I and II degree of severity were selected for the research. In the experimental groups of patients, an immunoassay was used to determine the marker level of bone marrow metabolism (MMP-8) in the oral fluid, in the dynamics of treatment. During the study, the content of this enzyme was found to be indicative of the transformation of the inflammatory process in the gums into the destruction of the alveolar bone. 20 A. Yu. Lukash et al. The obtained values of the concentration of MMP-8 in the oral fluid, as well as their dynamics, proved this marker to be indicative of the course of the inflammatory-destructive process in periodontal tissues, and therefore the possibility of its application for the diagnosis and monitoring of the results of treatment of generalized periodontitis","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127589334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endothelial progenitor cell dysfunction in diabetes mellitus: new target for risk stratification and therapies?","authors":"A. Berezin, A. Berezin","doi":"10.12988/bmgt.2019.915","DOIUrl":"https://doi.org/10.12988/bmgt.2019.915","url":null,"abstract":"","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129239262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of the heat shock protein HSP70 modulators on the energy metabolism of the rats brain in acute cerebral ischemia","authors":"I. Belenichev, Y. Bila","doi":"10.12988/BMGT.2019.949","DOIUrl":"https://doi.org/10.12988/BMGT.2019.949","url":null,"abstract":"","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113984371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.12988/bmgt.2019.91012
N. G. Ryndina
Introduction. When arterial hypertension (AH) is combined with rheumatoid arthritis (RA), there are significant imbalances between the production of lipid peroxidation (LP) derivatives and the ability to neutralize these reactive substances. Aim of the study: To investigate the lipid profile, the thickness of the intimamedia complex (TIMC) of common carotid arteries in patients with rheumatoid arthritis in combination with arterial hypertension, and to correlate these indicators with the manifestations of oxidative stress, and the antioxidant system. Materials and methods: The results of the study are based on a comprehensive survey of 96 patients with stage 2 hypertension in combination with RA, 45 patients with stage 2 hypertension and 31 healthy volunteers. Research results. The stage of hypertension significantly influenced the manifestations of atherosclerotic process and oxidative stress, average TIMC indexes of the right CCA 1.28 (1.08; 1.30) mm and left CCA 1.29 (1.06; 1.30) mm in patients with RA in combination with stage 2 AH were significantly higher by 24.2% and 24%, respectively, against rates of RA patients in combination with grade 1 AH (p <0.01). The detection rate of atherosclerotic plaques in the subgroup of RA patients 102 Nataly G. Ryndina in combination with grade 2 AH was significantly higher 10 times, compared to the subgroup of RA patients in combination with stage 1 AH (p <0.01). Significant relation between LP products indices and manifestations of atherosclerotic process in patients with hypertension in combination with RA, direct linear correlation of medium strength between indices of malonic aldehyde and LDL R = + 0,57, TG R = + 0,56, TIMC R = + 0.55, respectively (p <0.05), diene ketones and TG R = + 0.52, TG R = + 0.55, respectively (p <0.05). Conclusions. The highest predictive value for the detection of atheromatous plaques in the CCA system had malonic aldehyde (AUC 0.870, 95% CI AUC 0.784 to 0.931) at the optimum distribution point > 5.25 nmol/ml, sensitivity 88.73%, and specificity 90.43%, and diene ketones (AUC 0.869, 95% CI AUC 0.784 to 0.930) sensitivity 90.36% and specificity 88.87% at the optimum distribution point > 5 c.un./ml.
{"title":"Relation of the atherosclerotic process with the manifestation of oxidative stress in arterial hypertension patients combined with rheumatoid arthritis","authors":"N. G. Ryndina","doi":"10.12988/bmgt.2019.91012","DOIUrl":"https://doi.org/10.12988/bmgt.2019.91012","url":null,"abstract":"Introduction. When arterial hypertension (AH) is combined with rheumatoid arthritis (RA), there are significant imbalances between the production of lipid peroxidation (LP) derivatives and the ability to neutralize these reactive substances. Aim of the study: To investigate the lipid profile, the thickness of the intimamedia complex (TIMC) of common carotid arteries in patients with rheumatoid arthritis in combination with arterial hypertension, and to correlate these indicators with the manifestations of oxidative stress, and the antioxidant system. Materials and methods: The results of the study are based on a comprehensive survey of 96 patients with stage 2 hypertension in combination with RA, 45 patients with stage 2 hypertension and 31 healthy volunteers. Research results. The stage of hypertension significantly influenced the manifestations of atherosclerotic process and oxidative stress, average TIMC indexes of the right CCA 1.28 (1.08; 1.30) mm and left CCA 1.29 (1.06; 1.30) mm in patients with RA in combination with stage 2 AH were significantly higher by 24.2% and 24%, respectively, against rates of RA patients in combination with grade 1 AH (p <0.01). The detection rate of atherosclerotic plaques in the subgroup of RA patients 102 Nataly G. Ryndina in combination with grade 2 AH was significantly higher 10 times, compared to the subgroup of RA patients in combination with stage 1 AH (p <0.01). Significant relation between LP products indices and manifestations of atherosclerotic process in patients with hypertension in combination with RA, direct linear correlation of medium strength between indices of malonic aldehyde and LDL R = + 0,57, TG R = + 0,56, TIMC R = + 0.55, respectively (p <0.05), diene ketones and TG R = + 0.52, TG R = + 0.55, respectively (p <0.05). Conclusions. The highest predictive value for the detection of atheromatous plaques in the CCA system had malonic aldehyde (AUC 0.870, 95% CI AUC 0.784 to 0.931) at the optimum distribution point > 5.25 nmol/ml, sensitivity 88.73%, and specificity 90.43%, and diene ketones (AUC 0.869, 95% CI AUC 0.784 to 0.930) sensitivity 90.36% and specificity 88.87% at the optimum distribution point > 5 c.un./ml.","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133436832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.12988/bmgt.2019.91013
I. Belenichev, L. Kucherenko, I. Mazur, R. Akopyan, E. A. Portnaya
Age-related cataract is currently the leading cause of incurable blindness in the world and the most common eye disease in people over 60 years. Among all ophthalmic diseases, cataract is about 65%. The following medicines are used to treat cataracts: Oftan Catachrom (Santen AO, Finland), Taufon (Farmak, OAO, Kiev, Ukraine.), Quinax (Alcon -Couvreur, Belgium), Vita-Iodurol (Excelvision AG for Novartis Pharma AG, France/Switzerland), Potassium iodide (OOO “UNIMED PHARMA”, Slovak Republic). Based on the foregoing, it is clear that the range of drugs for the treatment of cataracts is limited, and mainly consists of imported drugs. All of the above opens up new prospects for the creation of new ophthalmic medicines for expanding the range of domestic drugs, namely eye drops with wound healing, reparative, anti-inflammatory effects. Therefore, the aim of our work is to create a new ophthalmic drug based on the original substance Angiolin, which will exhibit anti-inflammatory, wound healing, reparative properties. cataract was reproduced on both eyes of 10 animals (20 eyes) by chemical induction of free radical oxidation of biopolymers of eye tissues according to the D.K. Buyan method, for which 30 μl of a sterile solution of dibromide diquat at a dose of 600 nmol was injected once into the vitreous body. Treatment began from 7 days, when the initial opacity of the lens was formed, and was carried out by instillation of drugs into the conjunctival cavity of the eyes 3 times a day. Results: the course administration of 1% Angiolin eye drops had a significant therapeutic effect in the conditions of chemical cataracts. The use of Angiolin drops reduced the lens opacity of the eye of experimental animals by 43,5%. Findings: 1% Angiolin eye drops ((S) -2,6-diaminohexanoic acid 3-methyl-1,2,4-triazolyl-5-thioacetate) as an active ingredient, exhibit significant anti-inflammatory, wound healing, reparative properties, and also have a high therapeutic effect in the treatment of cataracts.
老年性白内障是目前世界上无法治愈的失明的主要原因，也是60岁以上人群中最常见的眼病。在所有眼科疾病中，白内障约占65%。以下药物用于治疗白内障:Oftan Catachrom (Santen AO，芬兰)，Taufon (Farmak, OAO，乌克兰基辅)，Quinax (Alcon -Couvreur，比利时)，Vita-Iodurol (Excelvision AG for Novartis Pharma AG，法国/瑞士)，碘化钾(OOO“UNIMED Pharma”，斯洛伐克共和国)。综上所述，治疗白内障的药物范围是有限的，而且主要是进口药物。所有这些都为创造新的眼科药物开辟了新的前景，扩大了国产药物的范围，即具有伤口愈合，修复，抗炎作用的眼药水。因此，我们的工作目标是在原物质血管素的基础上研制一种具有抗炎、伤口愈合、修复功能的新型眼科药物。采用布扬(D.K. Buyan)方法，在玻璃体内注射剂量为600 nmol的双溴双喹特无菌溶液30 μl，化学诱导眼组织生物聚合物自由基氧化，使10只动物(20只眼)双眼再生白内障。治疗从晶状体最初混浊形成的第7天开始，通过每天3次在眼睛结膜腔内滴注药物进行。结果:1%血管素滴眼液治疗化学性白内障疗效显著。血管素滴剂的使用使实验动物的晶状体混浊率降低了43.5%。结果:1%血管素滴眼液((S) -2,6-二氨基己酸3-甲基-1,2,4-三唑基-5-硫乙酸酯)作为有效成分，具有显著的抗炎、伤口愈合、修复作用，对白内障的治疗也有较高的疗效。
{"title":"Experimental assessment of the specific activity of a new dosage form of angiolin in cataract modeling","authors":"I. Belenichev, L. Kucherenko, I. Mazur, R. Akopyan, E. A. Portnaya","doi":"10.12988/bmgt.2019.91013","DOIUrl":"https://doi.org/10.12988/bmgt.2019.91013","url":null,"abstract":"Age-related cataract is currently the leading cause of incurable blindness in the world and the most common eye disease in people over 60 years. Among all ophthalmic diseases, cataract is about 65%. The following medicines are used to treat cataracts: Oftan Catachrom (Santen AO, Finland), Taufon (Farmak, OAO, Kiev, Ukraine.), Quinax (Alcon -Couvreur, Belgium), Vita-Iodurol (Excelvision AG for Novartis Pharma AG, France/Switzerland), Potassium iodide (OOO “UNIMED PHARMA”, Slovak Republic). Based on the foregoing, it is clear that the range of drugs for the treatment of cataracts is limited, and mainly consists of imported drugs. All of the above opens up new prospects for the creation of new ophthalmic medicines for expanding the range of domestic drugs, namely eye drops with wound healing, reparative, anti-inflammatory effects. Therefore, the aim of our work is to create a new ophthalmic drug based on the original substance Angiolin, which will exhibit anti-inflammatory, wound healing, reparative properties. cataract was reproduced on both eyes of 10 animals (20 eyes) by chemical induction of free radical oxidation of biopolymers of eye tissues according to the D.K. Buyan method, for which 30 μl of a sterile solution of dibromide diquat at a dose of 600 nmol was injected once into the vitreous body. Treatment began from 7 days, when the initial opacity of the lens was formed, and was carried out by instillation of drugs into the conjunctival cavity of the eyes 3 times a day. Results: the course administration of 1% Angiolin eye drops had a significant therapeutic effect in the conditions of chemical cataracts. The use of Angiolin drops reduced the lens opacity of the eye of experimental animals by 43,5%. Findings: 1% Angiolin eye drops ((S) -2,6-diaminohexanoic acid 3-methyl-1,2,4-triazolyl-5-thioacetate) as an active ingredient, exhibit significant anti-inflammatory, wound healing, reparative properties, and also have a high therapeutic effect in the treatment of cataracts.","PeriodicalId":150008,"journal":{"name":"Biological Markers and Guided Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128303933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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