大鼠半时、同步深部脑刺激和多位点记录

T. Gritsun, M. Litza, A. Hiller, A. Moser, U. Hofmann
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引用次数: 1

摘要

多位点微电极记录是一种在短时间尺度上研究中枢神经系统微生理和网络相互作用的合适方法。这使我们能够更深入地了解最近的神经化学研究,以研究脑深部刺激在同一位置引起的神经递质GABA的变化。我们在下面描述了一个半慢程序,将一个微型系统在自由行为的大鼠尾状壳核中近距离植入刺激和监测探针。新的多位点微电极取代现有的微透析探针由纺丝制成,表征和描述。讨论了闭环记录与激励系统的设计
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Semichronic, Collocated Deep Brain Stimulation and Multisite Recording in Rats
Multisite microelectrode recording represents a suitable procedure to study microphysiology and network interactions in the central nervous system on a short time scale. This enables a deeper understanding of recent neurochemical studies to investigate changes in the neurotransmitter GABA caused by deep brain stimulation at the same position. We describe in the following a semichronic procedure to implant a miniature system bringing both stimulation and monitoring probes in close proximity in the caudate putamen of freely behaving rats. New multisite microelectrodes to replace existing microdialysis probes are built from spun wires, characterized and described. The design of a closed loop recording and stimulating system is discussed
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