Risk factors for mortality in hospitalized moderate-to-severe COVID-19 patients: A single-center retrospective study

Aims: The aim of this study was to determine the mortality risk factors of hospitalized moderate-to-severe coronavirus disease 2019 (COVID-19) patients in Tehran. Materials and Methods: We retrospectively evaluated the baseline characteristics and clinical and paraclinical parameters of 223 deceased and discharged patients who were hospitalized in Firoozabadi General Hospital between March 1 and April 1, 2020. Results: According to our multiple logistic regression model, advanced age (odds ratio [OR], 1.06; 95% confidence interval [CI], 1.02–1.09; P < 0.01), reduced oxygen saturation (OR, 0.92; 95% CI, 0.87–0.96; P < 0.01), and hypertension (OR, 2.59; 95% CI, 1.04–6.46; P = 0.04) can be perceived as independent risk factors for mortality. Conclusion: Our results suggest that patients with older age, lower oxygen saturation, and hypertension are predisposed to an increased risk of mortality. Thus, to lower the COVID-19 mortality rates, patients with these characteristics should be the primary targets for early treatment, vaccination, or monitoring strategies.