A controlled clinical study to evaluate the efficacy of Janu Basti and Asthi Shrinkhala in management of Janusandhigata Vata w.s.r to Osteoarthritis

Background : Sandhigata Vata is characterized by Shoola (pain), Shopha (swelling) and restricted movement of affected joints. Osteoarthritis is characterized by inflammation of joints, marked by progressive cartilage damage as a result of age related degenerative change or trauma. Sandhigata Vata correlates with Osteoarthritis. Objectives - The present study was intended to evaluate and compare the efficacy of Asthishrinkhala (Trial drug) and Glucosamine sulfate (Control drug) in Janusandhigatavata w.s.r to Osteoarthritis. Materials and Method - 40 subjects diagnosed with Janusandhigatavata were randomly assigned into two equal groups comprising of 20 subjects each. Subjects of Group A received Janubasti with Mahavishagarbha Taila and Tab. Glucosamine sulfate 500mg 1 T.I.D after food and subjects of Group B received Janubasti with Mahavishagarbha Taila and Tab. Asthishrinkhala 500mg 1 T.I.D after food for a duration of 30 days. Observation and Results - In the present study, Asthishrinkhala and Glucosamine sulfate both were beneficial in reducing the symptoms of Janu Sandhigata Vata. On comparison between the groups, Glucosamine sulfate was more in beneficial in reducing the symptom of Janu Sandhigata Vata compared to Asthishrinkhala. However there was a statistically non significant result between groups, overall the subjects on glucosamine sulfate expressed greater benefit compared to Asthishrinkhala. Conclusion - Both the drugs were beneficial in managing the symptoms of Sandigatavata, but overall the subjects treated with glucosamine sulfate expressed greater benefits compared to subjects treated with Asthishrinkhala.